Titre:	A greener approach for the synthesis of pyrido[2,3-d]pyrimidine derivatives in glycerol under microwave heating
Auteur(s):	Martinho, Luan Alves Andrade, Carlos Kleber Zago de
metadata.dc.identifier.orcid:	https://orcid.org/0000-0001-6658-5847 https://orcid.org/0000-0003-0798-9133
metadata.dc.contributor.affiliation:	Universidade de Brasília, Instituto de Química, Laboratório de Química Metodológica e Orgânica Sintética (LaQMOS) Universidade de Brasília, Instituto de Química, Laboratório de Química Metodológica e Orgânica Sintética (LaQMOS)
Assunto::	Solventes orgânicos Pirido[2,3-d]pirimidinas
Date de publication:	aoû-2022
Editeur:	Wiley
Référence bibliographique:	MARTINHO, Luan Alves. ANDRADE, Carlos Kleber Zago. A greener approach for the synthesis of pyrido[2,3-d]pyrimidine derivatives in glycerol under microwave heating. Journal of Heterocyclic Chemistry, [S. l.], v. 59, n. 8, p. 1417-1429, 2022. DOI: https://doi.org/10.1002/jhet.4483. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1002/jhet.4483. Acesso em: 16 ago. 2026.
Abstract:	Herein, we report the multicomponent synthesis of pyrido[2,3‐d]pyrimidine derivatives from 6‐aminouracil, aromatic aldehydes, and malononitrile in glycerol as a green solvent under microwave heating. This methodology shows several advantages: catalyst‐free synthesis, up to 90% yield, operational simplicity, short reaction times, easy work‐up procedure, and a greener approach compared with other methods reported in the literature.
metadata.dc.description.unidade:	Instituto de Química (IQ)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Química
DOI:	https://doi.org/10.1002/jhet.4483
metadata.dc.relation.publisherversion:	https://onlinelibrary.wiley.com/doi/10.1002/jhet.4483
Agência financiadora:	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Universidade de Brasília, Grant/Award Number: Edital004/2021DPG
Collection(s) :	Artigos publicados em periódicos e afins

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