http://repositorio.unb.br/handle/10482/55675| Title: | A greener approach for the synthesis of pyrido[2,3-d]pyrimidine derivatives in glycerol under microwave heating |
| Authors: | Martinho, Luan Alves Andrade, Carlos Kleber Zago de |
| metadata.dc.identifier.orcid: | https://orcid.org/0000-0001-6658-5847 https://orcid.org/0000-0003-0798-9133 |
| metadata.dc.contributor.affiliation: | Universidade de Brasília, Instituto de Química, Laboratório de Química Metodológica e Orgânica Sintética (LaQMOS) Universidade de Brasília, Instituto de Química, Laboratório de Química Metodológica e Orgânica Sintética (LaQMOS) |
| Assunto:: | Solventes orgânicos Pirido[2,3-d]pirimidinas |
| Issue Date: | Aug-2022 |
| Publisher: | Wiley |
| Citation: | MARTINHO, Luan Alves. ANDRADE, Carlos Kleber Zago. A greener approach for the synthesis of pyrido[2,3-d]pyrimidine derivatives in glycerol under microwave heating. Journal of Heterocyclic Chemistry, [S. l.], v. 59, n. 8, p. 1417-1429, 2022. DOI: https://doi.org/10.1002/jhet.4483. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1002/jhet.4483. Acesso em: 16 ago. 2026. |
| Abstract: | Herein, we report the multicomponent synthesis of pyrido[2,3‐d]pyrimidine derivatives from 6‐aminouracil, aromatic aldehydes, and malononitrile in glycerol as a green solvent under microwave heating. This methodology shows several advantages: catalyst‐free synthesis, up to 90% yield, operational simplicity, short reaction times, easy work‐up procedure, and a greener approach compared with other methods reported in the literature. |
| metadata.dc.description.unidade: | Instituto de Química (IQ) |
| metadata.dc.description.ppg: | Programa de Pós-Graduação em Química |
| DOI: | https://doi.org/10.1002/jhet.4483 |
| metadata.dc.relation.publisherversion: | https://onlinelibrary.wiley.com/doi/10.1002/jhet.4483 |
| Agência financiadora: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Universidade de Brasília, Grant/Award Number: Edital004/2021DPG |
| Appears in Collections: | Artigos publicados em periódicos e afins |
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