Título:	Polimorfismo de nucleotídeo único na predição de radiodermatite em pacientes com câncer de mama : revisão sistemática e meta-análise
Autor(es):	Aguiar, Beatriz Regina Lima de
E-mail do autor:	beatrizregina.rla@gmail.com
Orientador(es):	Reis, Paula Elaine Diniz dos
Assunto:	Radiodermatite Radioterapia Marcadores genéticos Neoplasias Mamas - câncer Metanálise
Data de publicação:	19-Jul-2024
Data de defesa:	24-Set-2021
Referência:	AGUIAR, Beatriz Regina Lima de. Polimorfismo de nucleotídeo único na predição de radiodermatite em pacientes com câncer de mama: revisão sistemática e meta-análise. 2021. 154 f., il. Dissertação (Mestrado em Ciências da Saúde) — Universidade de Brasília, Brasília, 2021.
Abstract:	Introduction: Acute radiation dermatitis is a very common adverse reaction to radiotherapy in patients with breast cancer, which affects the quality of life, aesthetics, and body image, in addition to interrupting treatment in cases of a severe reaction. Radiogenomics studies the potential of Single Nucleotide Polymorphisms (SNPs) to predict radiosensitivity. Objective: To evaluate the potential of SNPs to predict the development or the severity of acute radiation dermatitis in breast cancer patients undergoing radiotherapy. Method: This is a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA 2020), published in 2020. The search was performed in CINAHL, Cochrane CENTRAL, EMBASE, LILACS, PubMed, Scopus, and Web of Science databases. Additionally, a search was made in the gray literature (Google Scholar, OpenGrey, and PROQUEST Thesis & Dissertations) and a manual search in the reference list of the articles included. The Critical Appraisal Checklist for Cohort Studies tool of the Joanna Briggs Institute was used to assess the risk of bias for individual studies. Meta-analysis of the prevalence of SNPs in breast cancer patients who had radiation dermatitis was performed in MetaXL® 5.3 software. Meta-analysis of the association between SNPs and radiation dermatitis severity was performed using Cochrane Collaboration's Review Manager® 5.4 software (RevMan 5.4). The certainty of the evidence was assessed using the Grading of Recommendation, Assessment, Development, and Evaluation tool. Results: Sixteen cohorts met the eligibility criteria and were included in this review. Thirteen studies had a low risk of bias, and three had a moderate risk of bias. Twenty-two SNPs were included in the prevalence meta-analysis. The two most prevalent single nucleotide polymorphisms in breast cancer that present radiation dermatitis were rs1800469 in the TGFβ1 gene (41%), and rs3957356 in the GSTA1 gene (36%) (I² ≥ 92%; p = 0). The association meta-analysis of 21 SNPs showed that seven genotypes are associated with severe radiation dermatitis and five genotypes are associated with lower radiation dermatitis. However, the only ones that showed low certainty of evidence were the CT genotype of the rs3957356 polymorphism in the GSTA1 gene and the GG genotype of the rs2282367 polymorphism in the MAT1A gene. All other genotypes have very low evidence certainty. Conclusion: Significant data show that genotyping of SNPs may be a strategy for predicting radiation dermatitis in breast cancer patients. It is suggested that studies of high methodological rigor to evaluate SNPs that presented high prevalend and that demonstrated a first possibility of association with radiation dermatitis be performed to confirm this hypothesis. Furthermore, studies with populations of different ethnicities and geographic locations are needed to assess SNPs in various populations.
Informações adicionais:	Dissertação (mestrado) — Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, 2021.
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências da Saúde
Licença:	A concessão da licença deste item refere-se ao termo de autorização impresso assinado pelo autor com as seguintes condições: Na qualidade de titular dos direitos de autor da publicação, autorizo a Universidade de Brasília e o IBICT a disponibilizar por meio dos sites www.bce.unb.br, www.ibict.br, http://hercules.vtls.com/cgi-bin/ndltd/chameleon?lng=pt&skin=ndltd sem ressarcimento dos direitos autorais, de acordo com a Lei nº 9610/98, o texto integral da obra disponibilizada, conforme permissões assinaladas, para fins de leitura, impressão e/ou download, a título de divulgação da produção científica brasileira, a partir desta data.
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