Título:	Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus
Autor(es):	Sousa, Davi Emanuel Ribeiro de Wilson, Tais Meziara Macêdo, Isabel Luana de Romano, Alessandro Pecego Martins Ramos, Daniel G. Passos, Pedro Henrique de Oliveira Costa, Gabriela R. T. Fonseca, Vagnerde Souza Mares-Guia, Maria Angélica M. M. Giovantetti, Marta Alcantara, Luiz Carlos Junior Filippis, Ana Maria B. de Paludo, Giane Regina Melo, Cristiano Barros de Castro, Márcio Botelho de
Afiliação do autor:	University of Brasília, Graduate Program in Animal Science University of Brasília, Veterinary Pathology Laboratory University of Brasília, Graduate Program in Animal Science University of Brasília, Veterinary Pathology Laboratory University of Brasília, Graduate Program in Animal Science University of Brasília, Veterinary Pathology Laboratory Brazilian Ministry of Health, Technical Group of Arbovirus Surveillance, Secretariat of Health Surveillance, Department of Communicable Disease Surveillance, General Coordination of Communicable Diseases Brazilian Ministry of Health, Technical Group of Arbovirus Surveillance, Secretariat of Health Surveillance, Department of Communicable Disease Surveillance, General Coordination of Communicable Diseases Brazilian Ministry of Health, Technical Group of Arbovirus Surveillance, Secretariat of Health Surveillance, Department of Communicable Disease Surveillance, General Coordination of Communicable Diseases University of Brasília, Graduate Program in Animal Science Environmental Health Surveillance Directorate of the Federal District Organização Pan-Americana da Saúde/ Organização Mundial da Saúde, Brasília, Brazil Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil Instituto Osawldo Cruz, Fiocruz, Laboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Rio de Janeiro, Brazil Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil Sciences and Technologies for Sustainable Development and One Health, University of Campus Bio-Medico of Rome, Rome, Italy Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil Instituto Osawldo Cruz, Fiocruz, Laboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Rio de Janeiro, Brazil Instituto Osawldo Cruz, Fiocruz, Laboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Rio de Janeiro, Brazil University of Brasília, Graduate Program in Animal Science University of Brasília, Graduate Program in Animal Science University of Brasília, Graduate Program in Animal Science University of Brasília, Veterinary Pathology Laboratory
Assunto:	Primata não humano Toxoplasma gondii Doenças infecciosas Vigilância sanitária Zoonoses
Data de publicação:	21-Ago-2023
Editora:	Frontiers
Referência:	SOUSA, Davi E. R. et al. Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus. Frontiers Public Health, v. 11, 21 ago. 2023. DOI: https://doi.org/10.3389/fpubh.2023.1236384. Disponível em: https://www.frontiersin.org/articles/10.3389/fpubh.2023.1236384/full. Acesso em: 23 jan. 2024.
Abstract:	Free-ranging non-human primates (NHP) can live in anthropized areas or urban environments in close contact with human populations. This condition can enable the emergence and transmission of high-impact zoonotic pathogens. For the first time, we detected a coinfection of the yellow fever (YF) virus with Toxoplasma gondii in a free-ranging NHP in a highly urbanized area of a metropolis in Brazil. Specifically, we observed this coinfection in a black-tufted marmoset found dead and taken for a necropsy by the local health surveillance service. After conducting an epidemiological investigation, characterizing the pathological features, and performing molecular assays, we confirmed that the marmoset developed an acute fatal infection caused by T. gondii in coinfection with a new YF virus South American-1 sub-lineage. As a result, we have raised concerns about the public health implications of these findings and discussed the importance of diagnosis and surveillance of zoonotic agents in urbanized NHPs. As competent hosts of zoonotic diseases such as YF and environmental sentinels for toxoplasmosis, NHPs play a crucial role in the One Health framework to predict and prevent the emergence of dangerous human pathogens.
Unidade Acadêmica:	Faculdade de Agronomia e Medicina Veterinária (FAV)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências Animais
Licença:	COPYRIGHT © 2023 Sousa, Wilson, Macêdo, Romano, Ramos, Passos, Costa, Fonseca, Mares-Guia, Giovanetti, Alcantara, de Filippis, Paludo, Melo and Castro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
DOI:	https://doi.org/10.3389/fpubh.2023.1236384
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