Título:	Health-related quality of life outcomes in head and neck cancer : results from a prospective, real-world data study with Brazilian patients treated with intensity modulated radiation therapy, conformal and conventional radiation techniques
Autor(es):	Santos, Marcos Silva, Luís Felipe Oliveira e Kohler, Hugo F. Curioni, Otavio Vilela, Ricardo Fang, Marcel Lima, Carmen Silvia Passos Gomes, João Pedro Chaves, Aline Resende, Bruno Trindade, Karine Collares, Mauricio Obs, Fernando Brollo, Janaina Cavalieri, Ronaldo Ferreira, Ediane Brust, Leandro Ramos, Doralina do Amaral Rabello Domenge, Christian Kowalski, Luiz Paulo
Afiliação do autor:	EORTC Quality of Life Group, Head and Neck Tumors, Brussels, Belgium Brasília University, Radiation therapy Department Brasília University, Radiation therapy Department AC Camargo Cancer Center–São Paulo Hospital Heliópolis, São Paulo Prevent Sênior, São Paulo Brasília University, Radiation therapy Department Prevent Sênior, São Paulo University of Campinas, Oncology Department University of Campinas, Oncology Department Santa Casa de Bagé Pontifícia Universidade Católica, Porto Alegre, Radiation therapy Department Hospital Geral de Caxias do Sul Oncobeda, Centro Integrado de Oncologia, Campos, RJ Brasília University, Radiation therapy Department Hospital Bruno Born, Lajeado, RS, Brazil Brasília University, Radiation therapy Department Société Franco-Brésilienne de Cancérologie, Nice, France AC Camargo Cancer Center–São Paulo
Assunto:	Qualidade de vida Saúde Cabeça - câncer Pescoço - câncer Radioterapia
Data de publicação:	21-Set-2020
Editora:	Elvsevier Inc.
Referência:	SANTOS, Marcos. Health-related quality of life outcomes in head and neck cancer: results from a prospective, real-world data study with Brazilian patients treated with intensity modulated radiation therapy, conformal and conventional radiation techniques. International Journal of Radiation Oncology*Biology*Physics, [S.l.], v. 109, n. 2, p. 485-494, 1 fev. 2020. DOI: https://doi.org/10.1016/j.ijrobp.2020.09.044.
Abstract:	Purpose: To compare global health-related quality of life (HRQoL) and overall survival (OS) in patients with head and neck cancer treated with intensity modulated radiation therapy (IMRT), conformal radiation therapy (3DCRT) or conventional ra- diation therapy (2DRT). Methods and Materials: In this real-world, multi-institutional and prospective study, HRQoL outcomes were assessed using the European Organisation for Research and Treatment of Cancer Quality-of-life Questionnaire Core 30 (EORTC QLQ-C30) and European Organisation for Research and Treatment of Cancer Quality-of-life Questionnaire Head and Neck 43 (H&N43) questionnaires. Item response theory was used to generate a global HRQoL score, based on the 71 questions from both forms. The effect of treatment modality on HRQoL was studied using multivariate regression analyses. Survival was estimated using the Kaplan-Meyer method, and groups were compared by the log-rank test. Results: Five hundred and seventy patients from 13 institutions were included. Median follow-up was 12.2 months. Concern- ing the radiation technique, 29.5% of the patients were treated with 2DRT, 43.7% received 3DCRT, and 26.8% were treated with IMRT. A higher proportion of patients receiving 2DRT had a treatment interruption of more than 5 days (69% vs 50.2% for 3DCRT and 42.5% for IMRT). IMRT had a statistically significant positive effect on HRQoL compared with 3DCRT (bZ 2.627, standard error Z 0.804, P Z .001) and 2DRT had a statistically significant negative effect compared with 3DCRT (bZ 5.075, standard error Z 0.926, P < .001). Patients receiving 2DRT presented a worse OS (P Z .01). There were no differences in OS when IMRT was compared with 3DCRT. Conclusions: IMRT provided better HRQoL than 3DCRT, which provided better HRQoL than 2DRT. Patients receiving 2DRT presented a worse OS, which might be related to more frequent treatment interruptions. Ó 2020 Elsevier Inc. All rights reserved.
DOI:	https://doi.org/10.1016/j.ijrobp.2020.09.044
Versão da editora:	https://www.sciencedirect.com/science/article/pii/S0360301620343467?via%3Dihub
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