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dc.contributor.authorSantos, Marcos-
dc.contributor.authorSilva, Luís Felipe Oliveira e-
dc.contributor.authorKohler, Hugo F.-
dc.contributor.authorCurioni, Otavio-
dc.contributor.authorVilela, Ricardo-
dc.contributor.authorFang, Marcel-
dc.contributor.authorLima, Carmen Silvia Passos-
dc.contributor.authorGomes, João Pedro-
dc.contributor.authorChaves, Aline-
dc.contributor.authorResende, Bruno-
dc.contributor.authorTrindade, Karine-
dc.contributor.authorCollares, Mauricio-
dc.contributor.authorObs, Fernando-
dc.contributor.authorBrollo, Janaina-
dc.contributor.authorCavalieri, Ronaldo-
dc.contributor.authorFerreira, Ediane-
dc.contributor.authorBrust, Leandro-
dc.contributor.authorRamos, Doralina do Amaral Rabello-
dc.contributor.authorDomenge, Christian-
dc.contributor.authorKowalski, Luiz Paulo-
dc.date.accessioned2023-10-09T14:34:21Z-
dc.date.available2023-10-09T14:34:21Z-
dc.date.issued2020-09-21-
dc.identifier.citationSANTOS, Marcos. Health-related quality of life outcomes in head and neck cancer: results from a prospective, real-world data study with Brazilian patients treated with intensity modulated radiation therapy, conformal and conventional radiation techniques. International Journal of Radiation Oncology*Biology*Physics, [S.l.], v. 109, n. 2, p. 485-494, 1 fev. 2020. DOI: https://doi.org/10.1016/j.ijrobp.2020.09.044.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/46640-
dc.language.isoengpt_BR
dc.publisherElvsevier Inc.pt_BR
dc.rightsAcesso Restritopt_BR
dc.titleHealth-related quality of life outcomes in head and neck cancer : results from a prospective, real-world data study with Brazilian patients treated with intensity modulated radiation therapy, conformal and conventional radiation techniquespt_BR
dc.typeArtigopt_BR
dc.subject.keywordQualidade de vidapt_BR
dc.subject.keywordSaúdept_BR
dc.subject.keywordCabeça - câncerpt_BR
dc.subject.keywordPescoço - câncerpt_BR
dc.subject.keywordRadioterapiapt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ijrobp.2020.09.044pt_BR
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0360301620343467?via%3Dihubpt_BR
dc.description.abstract1Purpose: To compare global health-related quality of life (HRQoL) and overall survival (OS) in patients with head and neck cancer treated with intensity modulated radiation therapy (IMRT), conformal radiation therapy (3DCRT) or conventional ra- diation therapy (2DRT). Methods and Materials: In this real-world, multi-institutional and prospective study, HRQoL outcomes were assessed using the European Organisation for Research and Treatment of Cancer Quality-of-life Questionnaire Core 30 (EORTC QLQ-C30) and European Organisation for Research and Treatment of Cancer Quality-of-life Questionnaire Head and Neck 43 (H&N43) questionnaires. Item response theory was used to generate a global HRQoL score, based on the 71 questions from both forms. The effect of treatment modality on HRQoL was studied using multivariate regression analyses. Survival was estimated using the Kaplan-Meyer method, and groups were compared by the log-rank test. Results: Five hundred and seventy patients from 13 institutions were included. Median follow-up was 12.2 months. Concern- ing the radiation technique, 29.5% of the patients were treated with 2DRT, 43.7% received 3DCRT, and 26.8% were treated with IMRT. A higher proportion of patients receiving 2DRT had a treatment interruption of more than 5 days (69% vs 50.2% for 3DCRT and 42.5% for IMRT). IMRT had a statistically significant positive effect on HRQoL compared with 3DCRT (bZ 2.627, standard error Z 0.804, P Z .001) and 2DRT had a statistically significant negative effect compared with 3DCRT (bZ 5.075, standard error Z 0.926, P < .001). Patients receiving 2DRT presented a worse OS (P Z .01). There were no differences in OS when IMRT was compared with 3DCRT. Conclusions: IMRT provided better HRQoL than 3DCRT, which provided better HRQoL than 2DRT. Patients receiving 2DRT presented a worse OS, which might be related to more frequent treatment interruptions. Ó 2020 Elsevier Inc. All rights reserved.pt_BR
dc.contributor.affiliationEORTC Quality of Life Group, Head and Neck Tumors, Brussels, Belgiumpt_BR
dc.contributor.affiliationBrasília University, Radiation therapy Departmentpt_BR
dc.contributor.affiliationBrasília University, Radiation therapy Departmentpt_BR
dc.contributor.affiliationAC Camargo Cancer Center–São Paulopt_BR
dc.contributor.affiliationHospital Heliópolis, São Paulopt_BR
dc.contributor.affiliationPrevent Sênior, São Paulopt_BR
dc.contributor.affiliationBrasília University, Radiation therapy Departmentpt_BR
dc.contributor.affiliationPrevent Sênior, São Paulopt_BR
dc.contributor.affiliationUniversity of Campinas, Oncology Departmentpt_BR
dc.contributor.affiliationUniversity of Campinas, Oncology Departmentpt_BR
dc.contributor.affiliationSanta Casa de Bagépt_BR
dc.contributor.affiliationPontifícia Universidade Católica, Porto Alegre, Radiation therapy Departmentpt_BR
dc.contributor.affiliationHospital Geral de Caxias do Sulpt_BR
dc.contributor.affiliationOncobeda, Centro Integrado de Oncologia, Campos, RJpt_BR
dc.contributor.affiliationBrasília University, Radiation therapy Departmentpt_BR
dc.contributor.affiliationHospital Bruno Born, Lajeado, RS, Brazilpt_BR
dc.contributor.affiliationBrasília University, Radiation therapy Departmentpt_BR
dc.contributor.affiliationSociété Franco-Brésilienne de Cancérologie, Nice, Francept_BR
dc.contributor.affiliationAC Camargo Cancer Center–São Paulopt_BR
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