Title:	SMYD2 is highly expressed in pediatric acute lymphoblastic leukemia and constitutes a bad prognostic factor
Authors:	Sakamoto, Luis Henrique Toshihiro Andrade, Rosângela Vieira de Felipe, Maria Sueli Soares Motoyama, Andrea Barretto Pittella-Silva, Fabio
metadata.dc.contributor.affiliation:	Universidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Patologia Molecular do Câncer Universidade Católica de Brasília, Laboratório de Ciências Genômicas e Biotecnologia Molecular Universidade de Brasília, Departamento de Biologia Celular Hospital Infantil José Alencar de Brasília
Assunto::	Proteínas Leucemia linfoblástica aguda (LLA) Infância Prognóstico Lisina Metiltransferase Expressão gênica
Issue Date:	Apr-2014
Publisher:	Elsevier
Citation:	SAKAMOTO, Luis Henrique Toshihiro et al. SMYD2 is highly expressed in pediatric acute lymphoblastic leukemia and constitutes a bad prognostic factor. Leukemia Research, v. 38, n. 4, p. 496-502, abr. 2014. DOI: https://doi.org/10.1016/j.leukres.2014.01.013.
Abstract:	Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Although several clinical characteristics can be associated with worse prognosis, more robust biological markers still remains uncovered. SMYD2, a member of SMYD protein family, regulates the activity of several proteins through methylation. In this study, we performed quantitative real time PCR to compare the expression of SMYD2 in 83 pediatric ALL patients and non-neoplastic bone marrow samples (BMS). The study revealed that SMYD2 expression is altered in ALL BMS and its high expression was correlated with a bad prognosis. Moreover, we also revealed that SMYD2 expression level significantly decreases in patients that respond to chemotherapy treatment.
DOI:	https://doi.org/10.1016/j.leukres.2014.01.013
metadata.dc.relation.publisherversion:	https://www.sciencedirect.com/science/article/pii/S0145212614000319?via%3Dihub
Appears in Collections:	Artigos publicados em periódicos e afins UnB - Professores Eméritos

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