Titre:	Organic beet leaves and stalk juice attenuates the glutathione peroxidase increase induced by high-fat meal in dyslipidemic patients : a pilot double-blind, randomized, controlled trial
Auteur(s):	Oliveira, Amanda Cristine de Gomes, Anna Paula Oliveira Rodrigues, Lorena Charife Cunha, Raisa da Silva Serra, Thaís Martins Schincaglia, Raquel Machado Silva, Marina Alves Coelho Horst, Maria Aderuza Rostagno, Maurício Ariel Magalhães, Kelly Grace Cunha, Luiz Carlos Botelho, Patrícia Borges
metadata.dc.identifier.orcid:	https://orcid.org/0000-0002-8869-5198 https://orcid.org/0000-0003-4325-7730 https://orcid.org/0000-0002-6249-8946 https://orcid.org/0000-0003-1763-5697 https://orcid.org/0000-0002-7435-5272 https://orcid.org/0000-0001-8909-3757
Assunto::	Antioxidantes Polifenóis
Date de publication:	2022
Editeur:	MDPI
Référence bibliographique:	OLIVEIRA, Amanda Cristine de et al. Organic beet leaves and stalk juice attenuates the glutathione peroxidase increase induced by high-fat meal in dyslipidemic patients: a pilot double-blind, randomized, controlled trial. Applied Sciences, v. 12, n. 4, 1973, 2022. DOI: https://doi.org/10.3390/app12041973. Disponível em: https://www.mdpi.com/2076-3417/12/4/1973. Acesso em: 2 jun. 2022.
Abstract:	The beet, including the leaves and stalk (BLS), is a vegetable with great antioxidant potential. The aim of this study was to evaluate the differences in the nutritional composition and the concentration of total phenolics between the organic and conventional BLS and to verify whether the ingestion of an organic BLS juice containing different concentrations of polyphenols modulated some biomarkers of oxidative stress after the ingestion of a high-fat meal in individuals with dyslipidemia. A controlled, randomized, double-blind, crossover clinical trial with a washout period of 1 week was carried out. A 12-h fasting blood sample was collected. Afterward, the participants consumed a high-fat meal, followed by the ingestion of a placebo or one of the organic BLS juices containing either 32.0 or 77.5 mg/100 mL of polyphenols. Blood samples were obtained 30, 60, 120 and 180 min after the first blood collection. The composition analysis showed that organic BLS had a better nutritional composition than conventional ones. The high-fat meal induced postprandial hypertriglyceridemia after 120 min (p < 0.001) and increased the concentration of malondialdehyde after 30 min (p < 0.001). In addition, there was a significant increase in GPx in 30 min (p = 0.026). This increase was attenuated in the group that received the highest dose of polyphenols when compared with the placebo after 30 min (p = 0.045). Therefore, the organic BLS juice containing 77.5 mg of polyphenols was efficient at modulating one of the postprandial mechanisms of enzymatic antioxidant protection in individuals with dyslipidemia.
Licença::	(CC BY)
DOI:	https://doi.org/10.3390/app12041973
Collection(s) :	Artigos publicados em periódicos e afins

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