Title:	Trend in infant mortality rate caused by sepsis in Brazil from 2009 to 2018
Authors:	Rodrigues, Liliane dos Santos Rodrigues, Livia dos Santos Costa, Luciana Cavalcante Fontoura, Guilherme Martins Gomes Maciel, Márcia Cristina Gonçalves
metadata.dc.identifier.orcid:	http://orcid.org/0000-0003-3132-2267 http://orcid.org/0000-0003-2933-6125 http://orcid.org/0000-0001-9246-9380 http://orcid.org/0000-0001-5430-0728 http://orcid.org/0000-0001-8782-4923
Assunto::	Mortalidade infantil Sepse Análise de séries temporais
Issue Date:	2021
Publisher:	Instituto de Medicina Tropical
Citation:	RODRIGUES, Liliane dos Santos et al. Trend in infant mortality rate caused by sepsis in Brazil from 2009 to 2018. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 63, e26, 2021. DOI: https://doi.org/10.1590/s1678-9946202163026. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652021000100215&lng=en&nrm=iso. Acesso em: 11 maio 2021.
Abstract:	Sepsis is the organ dysfunction resulting from an infection associated with an unregulated host inflammatory response, which generates high mortality rates in Brazil. The aim of this stydy was to analyze the trend of early, late and post-neonatal mortality rates due to sepsis in Brazilian regions, from 2009 to 2018. This is an ecological study of time series. The trend of infant mortality from sepsis was analyzed using the International Classification of Diseases (ICD10) according to the place of residence (North, Northeast, Southeast, South and Midwest). Death Certificate data were collected from the Mortality Information System database. The temporal trend was analyzed using the Prais-Winsten estimate, interpreted as increasing, decreasing or stable, through the dependent variable (logarithm of mortality rates) and interdependent variables (years of the historical series). The Stata 14.0 statistical software was used. There were 39,867 infant deaths due to sepsis (78.67% for unspecified bacterial sepsis of the neonate ). Most of the children were male, had mixed ethnicity (black and white) , were born preterm with low birth weight and most mothers were 20-34 years old. There were decreasing trends in mortality rates from 2009 to 2018: early neonatal, in the Southeast (-3.57%), North (-3.33%) and South (-2.91%); late neonatal, in the South (-4.12%), Southeast (-4.53%), North (-4.55%) and Midwest (-6.21%); and post-neonatal, in the Northeast (-1.84%), North (-3.62%), Southeast (-3.83%) and Midwest (-5.81%). The Northeast showed a stable trend in early and late neonatal mortality rates. It was concluded that most regions showed a decreasing trend in mortality rates from sepsis in all age components, despite regional differences.
Licença::	(CC BY NC) - This is an open-access article distributed under the terms of the Creative Commons Attribution License.
DOI:	https://doi.org/10.1590/s1678-9946202163026
Appears in Collections:	Artigos publicados em periódicos e afins

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