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dc.contributor.authorSilva, Calliandra Maria de Souza-
dc.contributor.authorHurtado, Fabián Andrés-
dc.contributor.authorTavares, Aldo Henrique Fonseca Pacheco-
dc.contributor.authorOliveira Júnior, Getúlio Pereira de-
dc.contributor.authorRaiol, Tainá-
dc.contributor.authorNishibe, Christiane-
dc.contributor.authorAgustinho, Daniel Paiva-
dc.contributor.authorAlmeida, Nalvo Franco-
dc.contributor.authorWalter, Maria Emília Machado Telles-
dc.contributor.authorNicola, André Moraes-
dc.contributor.authorBocca, Anamélia Lorenzetti-
dc.contributor.authorAlbuquerque, Patrícia-
dc.date.accessioned2021-05-19T12:58:29Z-
dc.date.available2021-05-19T12:58:29Z-
dc.date.issued2020-
dc.identifier.citationDE-SOUZA-SILVA, Calliandra M. et al. Transcriptional remodeling patterns in murine dendritic cells infected with Paracoccidioides brasiliensis : more is not necessarily better. Journal of Fungi, v. 6, n. 4, 311, 2020. DOI: https://doi.org/10.3390/jof6040311. Disponível em: https://www.mdpi.com/2309-608X/6/4/311. Acesso em: 19 maio 2021.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/40939-
dc.language.isoInglêspt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleTranscriptional remodeling patterns in murine dendritic cells infected with Paracoccidioides brasiliensis : more is not necessarily betterpt_BR
dc.typeArtigopt_BR
dc.subject.keywordParacoccidioides brasiliensispt_BR
dc.subject.keywordCélulas dendríticaspt_BR
dc.subject.keywordResistênciapt_BR
dc.subject.keywordAutofagiapt_BR
dc.subject.keywordFungospt_BR
dc.rights.licenseCopyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/jof6040311pt_BR
dc.description.abstract1Most people infected with the fungus Paracoccidioides spp. do not get sick, but approximately 5% develop paracoccidioidomycosis. Understanding how host immunity determinants influence disease development could lead to novel preventative or therapeutic strategies; hence, we used two mouse strains that are resistant (A/J) or susceptible (B10.A) to P. brasiliensis to study how dendritic cells (DCs) respond to the infection. RNA sequencing analysis showed that the susceptible strain DCs remodeled their transcriptomes much more intensely than those from the resistant strain, agreeing with a previous model of more intense innate immunity response in the susceptible strain. Contrastingly, these cells also repress genes/processes involved in antigen processing and presentation, such as lysosomal activity and autophagy. After the interaction with P. brasiliensis, both DCs and macrophages from the susceptible mouse reduced the autophagy marker LC3-II recruitment to the fungal phagosome compared to the resistant strain cells, confirming this pathway’s repression. These results suggest that impairment in antigen processing and presentation processes might be partially responsible for the inefficient activation of the adaptive immune response in this model.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9064-0735pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0579-3380pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6940-401Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2242-4798pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5615-1746pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8656-5835pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3323-5300pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8160-7784pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1403-9363pt_BR
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