Título :	Biopharmaceuticals from microorganisms : from production to purification
Autor :	Jozala, Angela Faustino Geraldes, Danilo Costa Tundisi, Louise Lacalendola Feitosa, Valker de Araújo Breyer, Carlos Alexandre Cardoso, Samuel Leite Mazzola, Priscila Gava Oliveira-Nascimento, Laura de Rangel-Yagui, Carlota de Oliveira Magalhães, Pérola de Oliveira Oliveira, Marcos Antonio de Pessoa Junior, Adalberto
Assunto::	Biofármacos Processo - fermentação Biotecnologia
Fecha de publicación :	dic-2016
Editorial :	Sociedade Brasileira de Microbiologia
Citación :	JOZALA, Angela Faustino et al. Biopharmaceuticals from microorganisms: from production to purification. Brazilian Journal of Microbiology, São Paulo, v. 47, supl. 1, p. 51-63, dez. 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000500051&lng=en&nrm=iso>. Acesso em: 20 dez. 2017. doi: http://dx.doi.org/10.1016/j.bjm.2016.10.007.
Abstract:	The use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.
Licença::	Brazilian Journal of Microbiology - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way (CC BY NC ND). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000500051&lng=en&nrm=iso. Acesso em: 20 dez. 2017.
DOI:	http://dx.doi.org/10.1016/j.bjm.2016.10.007
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