Título:	Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction
Autor(es):	Alecrim, Hugo Muscelli Duarte, Sérgio Andurte Carvalho Amaral, Maria Eduarda Bonavides Diógenis, Filipe Carneiro, Fabiana Pirani Sousa, João Batista de
Assunto:	Cólon (Anatomia) Cicatrização de feridas Cirurgia Ratos
Data de publicação:	Jan-2015
Editora:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Referência:	ALECRIM, Hugo Muscelli et al. Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction. Acta Cirurgica Brasileira, São Paulo, v. 30, n. 1, p. 73-79, jan. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100073&lng=en&nrm=iso>. Acesso em: 17 abr. 2018. doi: http://dx.doi.org/10.1590/S0102-86502015001000010.
Abstract:	Purpose: to evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats. Methods: sixteen male rats were allocated across four groups: LG - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct ligation until euthanasia. L - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. M - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. MG - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct manipulation until euthanasia. On the day of euthanasia, bursting pressure of the sutured bowel segment was measured and samples were collected for histopathological analysis. Results: there were no differences in bursting pressure among groups : LG vs. M (110 ± 28 vs. 173 ± 12; p = 0.08). Groups L and MG were not different from group M (156 ± 12 and 118 ± 22. Glutamine supplementation was associated with less edema, polymorphonuclear lymphocyte infiltration, bacterial colonies, and abscess formation, as well as with increased collagen formation. Conclusion: obstructive jaundice had no negative effect and glutamine supplementation had no positive effect on colonic scar strength in rats.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	Acta Cirurgica Brasileira - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY NC 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100073&lng=en&nrm=iso. Acesso em: 17 abr. 2018.
DOI:	http://dx.doi.org/10.1590/S0102-86502015001000010
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