Title:	Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying
Authors:	Parize, Alexandre Luis Stulzer, Hellen Karine Laranjeira, Mauro César Marghetti Brighente, Inês Maria da Costa Souza, Tereza Cristina Rozone de
Assunto::	Quitosana Curcumina Secagem
Issue Date:	2012
Publisher:	Sociedade Brasileira de Química
Citation:	PARIZE, Alexandre Luis et al. Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying. Química Nova, São Paulo, v. 35, n. 6, p. 1127-1132, 2012. DOI: https://doi.org/10.1590/S0100-40422012000600011. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600011&lng=en&nrm=iso&tlng=en. Acesso em: 22 out. 2020.
Abstract:	The aim of this study was to encapsulate curcumin into chitosan, using sodium tripolyphosphate (TPP) as an ionic crosslinker by the spray drying method. The influence of TPP on the properties of the final product, such as solubility, morphology, loading efficiency, thermal behavior, swelling degree and release profiles, was evaluated. The microparticles had a spherical morphology (0.5-20 µm) with no apparent porosity or cracks. Results indicated the formation of a polymeric network, which ensures effective protection for curcumin. Controlled-release studies were carried out at pH 1.2 and 6.8, to observe the influence of pH on curcumin release while the mechanism was analyzed using the Korsmeyer-Peppas equation.
metadata.dc.description.unidade:	Instituto de Química (IQ)
Licença::	Química Nova - (CC BY-NC) - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600011&lng=en&nrm=iso&tlng=en. Acesso em: 22 out. 2020.
DOI:	https://dx.doi.org/10.1590/S0100-40422012000600011
Appears in Collections:	Artigos publicados em periódicos e afins

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