Título:	Diacutaneous fibrolysis versus passive stretching after articular immobilisation : muscle recovery and extracellular matrix remodelling
Autor(es):	Martins, Wagner Rodrigues Carvalho, M. M. Mota, M. R. Cipriano, Graziella França Bernardelli Mendes, Felipe Augusto dos Santos Diniz, L. R. C. Júnior, G. Carregaro, Rodrigo Luiz Durigan, João Luiz Quagliotti
Assunto:	Fibrólise diacutânea Alongamento (Fisiologia) Atrofia muscular
Data de publicação:	21-Dez-2013
Editora:	OA Publishing London
Referência:	MARTINS, Wagner Rodrigues et al. Diacutaneous fibrolysis versus passive stretching after articular immobilisation: muscle recovery and extracellular matrix remodelling. OA Medical Hypothesis, v. 1, n. 2, 17, 21 dez. 2013. Disponível em: <http://www.oapublishinglondon.com/article/1023>. Acesso em: 22 maio 2017.
Abstract:	Introduction Atrophy and muscle shortening due to articular immobilisation are common problems in musculoskeletal rehabilitation. Muscle stretching mechanical stimuli might be considered as the golden standard procedure to improve muscle flexibility in rehabilitation. Muscle stretching generates mechanotransduction, potentiating specific gene expression and promotes sarcomerogenesis and extracellular matrix remodelling on shortened and atrophied muscles. Hypothesis Diacutaneous fibrolysis, like stretching, uses an external force to stress connective and muscle tissues mechanically to treat muscle shortening; thus, it is widely used in clinical practice even if there is no evidence to support it. Considering this subject, we have hypothesised that diacutaneous fibrolysis can generate mechanotransduction, affecting muscle hypertrophy and extracellular matrix remodelling after immobilisation. Evaluation of hypothesis We have designed a laboratory experimental study with a sample of 50 rats. The sample was randomly divided into five groups: Control group (n = 10) with non–immobilised rats; 3–week immobilisation group (n = 10); 3–week immobilisation/3–week non–immobilisation group (n = 10);3–week immobilisation/3–week stretching group (n = 10); and 3–week immobilisation/3–week diacutaneous fibrolysis group (n = 10). All rats had their left tibiotarsal joint immobilised in maximum plantar flexion with the orthotics for 3 consecutive weeks. After the immobilisation period, the intervention groups received their respective intervention on their left triceps suralis for 3 weeks. Dependent variables of the study were sarcomere analysis, polymerase chain reaction, connective tissue density, collagen birefringence and matrix metalloproteinases. Statistical analysis was performed using analysis of variance and Duncan post hoc test was applied for differences between groups. For all calculations, a 5% (p < 0.05) significance level was established. Conclusion If the hypothesis is confirmed, the present study might provide evidence to support the use of this physical therapy resource widely used to treat muscle dysfunctions.
Licença:	Licensee OA Publishing London 2013. Creative Commons Attribution License (CC-BY). Fonte: http://www.oapublishinglondon.com/article/1023. Acesso em: 22 maio 2017.
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