http://repositorio.unb.br/handle/10482/13144| Fichier | Description | Taille | Format | |
|---|---|---|---|---|
| ARTIGO_GQ16NovelPeroxisome.pdf | 2,69 MB | Adobe PDF | Voir/Ouvrir |
| Titre: | GQ-16, a novel peroxisome proliferator-activated receptor (PPAR ) ligand, promotes insulin sensitization without weight gain |
| Auteur(s): | Amato, Angélica Amorim Rajagopalan, Senapathy Lin, Jean Z. Carvalho, Bruno de Melo Figueira, Ana Carolina Migliorini Lu, Jenny Ayers, Stephen D. Mottin, Melina Silveira, Rodrigo Leandro Souza, Paulo Cesar Telles de Mourão, Rosa Helena Veras Saad, Mário José Abdalla Togashi, Marie Simeoni, Luiz Alberto Abdalla, Dulcineia Saes Parra Skaf, Munir Salomao Polikarpov, Igor Lima, Maria do Carmo Alves de Galdino, Suely Lins Brennan, Richard G. Baxter, John Darling Pitta, Ivan da Rocha Webb, Paul Phillips, Kevin J. Neves, Francisco de Assis Rocha |
| Assunto:: | Resistência à insulina Diabetes Medicamentos - uso terapêutico Ganho/Perda de peso |
| Date de publication: | 10-aoû-2012 |
| Editeur: | The American Society for Biochemistry and Molecular Biology, Inc. |
| Référence bibliographique: | AMATO, Angélica A. et al. GQ-16, a novel peroxisome proliferator-activated receptor (PPAR) ligand, promotes insulin sensitization without weight gain. The Journal of Biological Chemistry, v. 287, n. 33, p. 28169-28179, ago. 2012. Disponível em: <http://www.jbc.org/content/287/33/28169.full.pdf+html?sid=05080e27-cfc7-48aa-abf6-c1149dbce8ed>. Acesso em: 17 maio 2013. |
| Résumé: | ABSTRACT Background: PPAR agonists improve insulin sensitivity but also evoke weight gain. Results: GQ-16 is a PPAR partial agonist that blocks receptor phosphorylation by Cdk5 and improves insulin sensitivity in diabetic mice in the absence of weight gain. Conclusion: The unique binding mode of GQ-16 appears to be responsible for the compound’s advantageous pharmacological profile. Significance: Similar compounds could have promise as anti-diabetic therapeutics. |
| Licença:: | The Journal of Biological Chemistry - The final version of the manuscript will be covered under the Creative Commons Attribution license (CC BY), the most accommodating of licenses offered. Click here for details.The final version of the manuscript will be released immediately on the publisher’s website and PubMed Central. Fonte: http://www.jbc.org/site/misc/Copyright_Permission.xhtml |
| Collection(s) : | Artigos publicados em periódicos e afins |
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