Title:	Multimethod analysis of adherence to preventive treatment for tuberculosis : a pragmatic randomized clinical trial
Authors:	Alves, Bárbara Manuella Cardoso Sodré Araújo, Wildo Navegantes de Zimmermann, Ivan Ricardo Metzger, Ingrid Ferreira Verdam, Maria Christina dos Santos Cola, João Paulo Prado, Thiago Nascimento do Pereira, Leonardo Régis Leira Oliveira Filho, Alfredo Dias de Maciel, Ethel Leonor Noia Tavares, Noemia Urruth Leão
metadata.dc.identifier.orcid:	https://orcid.org/ 0000-0001-9875-4334
metadata.dc.contributor.affiliation:	Universidade de Brasília, Laboratory of Evidence and Pharmaceutical Studies Universidade de Brasília, Postgraduate Program in Pharmaceutical Sciences University of Brasília, Postgraduate Program in Collective Health University of Brasília, School of Medicine, Postgraduate Program in Tropical Medicine Universidade de Brasília, Faculdade UnB Ceilândia National Institute for Science and Technology for Health Technology Assessment Universidade de Brasília, Laboratory of Evidence and Pharmaceutical Studies University of Brasília, Postgraduate Program in Collective Health University of Brasília, School of Medicine, Postgraduate Program in Tropical Medicine Universidade de Brasília, Laboratory of Evidence and Pharmaceutical Studies Universidade Federal do Espírito Santo, Laboratory of Epidemiology, Postgraduate Program in Collective Health Universidade Federal do Espírito Santo, Laboratory of Epidemiology, Postgraduate Program in Collective Health University of São Paulo, Ribeirão Preto School of Pharmaceutical Sciences Federal University of Sergipe Universidade Federal do Espírito Santo, Laboratory of Epidemiology, Postgraduate Program in Collective Health Universidade de Brasília, Laboratory of Evidence and Pharmaceutical Studies University of Brasília, Postgraduate Program in Pharmaceutical Sciences
Assunto::	Tuberculose - tratamento preventivo Persistência terapêutica Isoniazida Tuberculose latente
Issue Date:	19-Mar-2026
Publisher:	Springer
Citation:	ALVES, Bárbara Manuella Cardoso Sodré et al. Multimethod analysis of adherence to preventive treatment for tuberculosis: a pragmatic randomized clinical trial. BMC Infections Diseases, v. 26, art. n. 975, 2026. DOI: https://doi.org/10.1186/s12879-026-13069-0. Disponível em: https://link.springer.com/article/10.1186/s12879-026-13069-0. Acesso em: 22 out. 2026.
Abstract:	Tuberculosis Preventive Treatment (TPT) can reduce the likelihood of active disease from 1.6% to 0.6% in contacts of infectious cases. In Brazil, four therapeutic regimens for Tuberculosis infection (TBI) are currently in use, with isoniazid (INH) being the predominant regimen. The perspective of study this study is that simplifying the regimen by reducing the number of tablets required per dose could lead to improved adherence to TPT. Therefore, in 2018, the INH 300 mg dosage (one tablet per day) was introduced to improve adherence, since previously, only the 100 mg presentation was available. The present study is a pragmatic randomized clinical trial to assess adherence to treatment with 300 mg INH versus 100 mg INH, which included volunteers aged over 18 years from February 2021 to July 2022. Adherence was measured in three ways: self-reported, treatment persistence and the medication possession ratio (MPR). The results demonstrated that the INH 300 mg group had lower dropout rates and higher adherence to treatment rates, although the difference was not statistically significant. The 300 mg INH group presented greater persistence, indicating a lower probability of abandonment. This study compared two presentations of INH for TPT: a control group, in which three 100 mg tablets were administered, and an intervention group, in which one 300 mg tablet was administered, and revealed several important trends. However, not all of them reached statistical significance. These findings may support the incorporation of new therapeutic strategies in the management of TBI, as well as improve regular follow-up by health professionals for people on TPT, with the aim of optimizing the results of control and elimination programs.
metadata.dc.description.unidade:	Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Ciências Farmacêuticas Programa de Pós-Graduação em Saúde Coletiva
Licença::	Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
DOI:	https://doi.org/10.1186/s12879-026-13069-0
Appears in Collections:	Artigos publicados em periódicos e afins

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