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dc.contributor.authorOliveira, Fernanda Bellaniza Caminha dept_BR
dc.contributor.authorFreire, Vanessa Paola Alves Sampaio de Sápt_BR
dc.contributor.authorCoelho, Sharton Vinicius Antunespt_BR
dc.contributor.authorMeuren, Lana Monteiropt_BR
dc.contributor.authorPalmeira, Julys da Fonsecapt_BR
dc.contributor.authorCardoso, Ana Luísapt_BR
dc.contributor.authorNeves, Francisco de Assis Rochapt_BR
dc.contributor.authorRibeiro, Bergmann Moraispt_BR
dc.contributor.authorArgañaraz, Gustavo Adolfopt_BR
dc.contributor.authorArruda, Luciana Barros dept_BR
dc.contributor.authorArgañaraz, Enrique Robertopt_BR
dc.date.accessioned2026-09-04T10:28:59Z-
dc.date.available2026-09-04T10:28:59Z-
dc.date.issued2023-5-26pt_BR
dc.identifier.citationOLIVEIRA, Fernanda Bellaniza Caminha de et al. Zikv strains elicit different inflammatory and anti-viral responses in microglia cells. Viruses, [S. l.], v. 15, n. 6, p. 1250, 2023. DOI: https://doi.org/10.3390/v15061250. Disponível em: https://www.mdpi.com/1999-4915/15/6/1250. Acesso em: 26 ago. 2026.pt_BR
dc.identifier.urihttps://doi.org/10.3390/v15061250pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/55848-
dc.language.isoeng-
dc.publisherMDPI AGpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleZikv strains elicit different inflammatory and anti-viral responses in microglia cellspt_BR
dc.typeArtigopt_BR
dc.subject.keywordVírus Zikapt_BR
dc.subject.keywordInfecções por vírus Zikapt_BR
dc.subject.keywordMicrógliapt_BR
dc.subject.keywordInflamaçãopt_BR
dc.rights.licenseThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).-
dc.identifier.doihttps://doi.org/10.3390/v15061250pt_BR
dc.description.abstract1In recent years, the Zika Virus (ZIKV) has caused pandemic outbreaks associated with a high rate of congenital ZIKV syndrome (CZS). Although all strains associated with worldwide outbreaks derive from the Asian lineage, the reasons for their enhanced spread and severity are not fully understood. In this study, we conducted a comparative analysis of miRNAs (miRNA-155/146a/124) and their cellular targets (SOCS1/3, SHP1, TRAF6, IRAK1), as well as pro- and anti-inflammatory and anti-viral cytokines (IL-6, TNF-α, IFN-γ, IL-10, and IFN-β) and peroxisome proliferator-activated receptor γ (PPAR-γ) expression in BV2 microglia cells infected with ZIKV strains derived from African and Asian lineages (ZIKVMR766 and ZIKVPE243). BV2 cells were susceptible to both ZIKV strains, and showed discrete levels of viral replication, with delayed release of viral particles without inducing significant cytopathogenic effects. However, the ZIKVMR766 strain showed higher infectivity and replicative capacity, inducing a higher expression of microglial activation markers than the ZIKVPE243 strain. Moreover, infection with the ZIKVMR766 strain promoted both a higher inflammatory response and a lower expression of anti-viral factors compared to the ZIKVPE243 strain. Remarkably, the ZIKKPE243 strain induced significantly higher levels of the anti-inflammatory nuclear receptor—PPAR-γ. These findings improve our understanding of ZIKV-mediated modulation of inflammatory and anti-viral innate immune responses and open a new avenue to explore underlining mechanisms involved in the pathogenesis of ZIKV-associated diseases.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0794-7160pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5145-4561pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7011-7197pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4359-7594pt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Science, Department of Pharmacy, Laboratory of Molecular Neurovirologypt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Science, Department of Pharmacy, Laboratory of Molecular Neurovirologypt_BR
dc.contributor.affiliationUniversidade Federal do Rio de Janeiro, Instituto de Microbiologia Paulo de Goes, Departamento de Virologia, Laboratório de Genética e Imunologia das Infecções Viraispt_BR
dc.contributor.affiliationUniversidade Federal do Rio de Janeiro, Instituto de Microbiologia Paulo de Goes, Departamento de Virologia, Laboratório de Genética e Imunologia das Infecções Viraispt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Science, Department of Pharmacy, Laboratory of Molecular Neurovirologypt_BR
dc.contributor.affiliationUniversity of Coimbra, Centre for Neuroscience and Cell Biologypt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Science, Laboratory of Molecular Pharmacologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Cell Biology Department, Laboratory of Bacuoloviruspt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Science, Department of Pharmacy, Laboratory of Molecular Neurovirologypt_BR
dc.contributor.affiliationUniversidade Federal do Rio de Janeiro, Instituto de Microbiologia Paulo de Goes, Departamento de Virologia, Laboratório de Genética e Imunologia das Infecções Viraispt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Science, Department of Pharmacy, Laboratory of Molecular Neurovirologypt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
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