Título:	Anti-inflammatory activity of pequi oil (caryocar brasiliense) : a systematic review
Autor(es):	Silva, Vitória Regina Pereira da Pinheiro, Andréia Camargo Ombredane, Alicia Simalie Martins, Natália Ornelas Luz, Glécia Virgolino da Silva Carneiro, Marcella Lemos Brettas Joanitti, Graziella A.
ORCID:	https://orcid.org/0000-0002-5385-6174 https://orcid.org/0000-0002-6165-0969
Afiliação do autor:	University of Brasilia, Faculty of Ceilandia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano) University of Brasilia, Faculty of Health Sciences, Post-Graduate Program in Pharmaceuticals Sciences University of Brasilia, Faculty of Ceilandia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano) University of Brasilia, Institute of Biological Sciences, Post-Graduation Program in Nanoscience and Nanobiotechnology University of Brasilia, Faculty of Ceilandia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano) University of Brasilia, Faculty of Ceilandia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano) University of Brasilia, Health Technology Assessment Center-NATS/UnB University of Brasilia, Faculty of Gama, Post-Graduation Program in Biomedical Engineering University of Brasilia, Faculty of Ceilandia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano) University of Brasilia, Institute of Biological Sciences, Post-Graduation Program in Nanoscience and Nanobiotechnology University of Brasilia, Faculty of Gama, Post-Graduation Program in Biomedical Engineering University of Brasilia, Faculty of Ceilandia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano) University of Brasilia, Institute of Biological Sciences, Post-Graduation Program in Nanoscience and Nanobiotechnology
Assunto:	Agentes antiinflamatórios Pequi Óleo de pequi Nanoemulsão
Data de publicação:	21-Dez-2023
Editora:	MDPI AG
Referência:	SILVA, Vitória R. P. et al. Anti-inflammatory activity of pequi oil (caryocar brasiliense): a systematic review. Pharmaceuticals, [S. l.], v. 17, n. 1, 11, 2023. DOI: https://doi.org/10.3390/ph17010011. Disponível em: https://doi.org/10.3390/ph17010011
Abstract:	Disorders in the inflammatory process underlie the pathogenesis of numerous diseases. The utilization of natural products as anti-inflammatory agents is a well-established approach in both traditional medicine and scientific research, with studies consistently demonstrating their efficacy in managing inflammatory conditions. Pequi oil, derived from Caryocar brasiliense, is a rich source of bioactive compounds including fatty acids and carotenoids, which exhibit immunomodulatory potential. This systematic review aims to comprehensively summarize the scientific evidence regarding the anti-inflammatory activity of pequi oil. Extensive literature searches were conducted across prominent databases (Scopus, BVS, CINAHL, Cochrane, LILACS, Embase, MEDLINE, ProQuest, PubMed, FSTA, ScienceDirect, and Web of Science). Studies evaluating the immunomodulatory activity of crude pequi oil using in vitro, in vivo models, or clinical trials were included. Out of the 438 articles identified, 10 met the stringent inclusion criteria. These studies collectively elucidate the potential of pequi oil to modulate gene expression, regulate circulating levels of pro- and anti-inflammatory mediators, and mitigate oxidative stress, immune cell migration, and cardinal signs of inflammation. Moreover, negligible to no toxicity of pequi oil was observed across the diverse evaluated models. Notably, variations in the chemical profile of the oil were noted, depending on the extraction methodology and geographical origin. This systematic review strongly supports the utility of pequi oil in controlling the inflammatory process. However, further comparative studies involving oils obtained via different methods and sourced from various regions are warranted to reinforce our understanding of its effectiveness and safety.
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências Farmacêuticas Programa de Pós-Graduação em Nanociência e Nanobiotecnologia
Licença:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).
DOI:	https://doi.org/10.3390/ph17010011
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