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dc.contributor.authorSilva, Vitória Regina Pereira dapt_BR
dc.contributor.authorPinheiro, Andréia Camargopt_BR
dc.contributor.authorOmbredane, Alicia Simaliept_BR
dc.contributor.authorMartins, Natália Ornelaspt_BR
dc.contributor.authorLuz, Glécia Virgolino da Silvapt_BR
dc.contributor.authorCarneiro, Marcella Lemos Brettaspt_BR
dc.contributor.authorJoanitti, Graziella Anselmopt_BR
dc.date.accessioned2026-08-19T15:33:11Z-
dc.date.available2026-08-19T15:33:11Z-
dc.date.issued2023-12-21pt_BR
dc.identifier.citationSILVA, Vitória R. P. et al. Anti-inflammatory activity of pequi oil (caryocar brasiliense): a systematic review. Pharmaceuticals, [S. l.], v. 17, n. 1, 11, 2023. DOI: https://doi.org/10.3390/ph17010011. Disponível em: https://doi.org/10.3390/ph17010011pt_BR
dc.identifier.urihttps://doi.org/10.3390/ph17010011pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/55709-
dc.language.isoeng-
dc.publisherMDPI AGpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleAnti-inflammatory activity of pequi oil (caryocar brasiliense) : a systematic reviewpt_BR
dc.typeArtigopt_BR
dc.subject.keywordAgentes antiinflamatóriospt_BR
dc.subject.keywordPequipt_BR
dc.subject.keywordÓleo de pequipt_BR
dc.subject.keywordNanoemulsãopt_BR
dc.rights.licenseThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/ph17010011pt_BR
dc.description.abstract1Disorders in the inflammatory process underlie the pathogenesis of numerous diseases. The utilization of natural products as anti-inflammatory agents is a well-established approach in both traditional medicine and scientific research, with studies consistently demonstrating their efficacy in managing inflammatory conditions. Pequi oil, derived from Caryocar brasiliense, is a rich source of bioactive compounds including fatty acids and carotenoids, which exhibit immunomodulatory potential. This systematic review aims to comprehensively summarize the scientific evidence regarding the anti-inflammatory activity of pequi oil. Extensive literature searches were conducted across prominent databases (Scopus, BVS, CINAHL, Cochrane, LILACS, Embase, MEDLINE, ProQuest, PubMed, FSTA, ScienceDirect, and Web of Science). Studies evaluating the immunomodulatory activity of crude pequi oil using in vitro, in vivo models, or clinical trials were included. Out of the 438 articles identified, 10 met the stringent inclusion criteria. These studies collectively elucidate the potential of pequi oil to modulate gene expression, regulate circulating levels of pro- and anti-inflammatory mediators, and mitigate oxidative stress, immune cell migration, and cardinal signs of inflammation. Moreover, negligible to no toxicity of pequi oil was observed across the diverse evaluated models. Notably, variations in the chemical profile of the oil were noted, depending on the extraction methodology and geographical origin. This systematic review strongly supports the utility of pequi oil in controlling the inflammatory process. However, further comparative studies involving oils obtained via different methods and sourced from various regions are warranted to reinforce our understanding of its effectiveness and safety.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5385-6174pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6165-0969pt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilandia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano)pt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Health Sciences, Post-Graduate Program in Pharmaceuticals Sciencespt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilandia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano)pt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduation Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilandia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano)pt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilandia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano)pt_BR
dc.contributor.affiliationUniversity of Brasilia, Health Technology Assessment Center-NATS/UnBpt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Gama, Post-Graduation Program in Biomedical Engineeringpt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilandia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano)pt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduation Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Gama, Post-Graduation Program in Biomedical Engineeringpt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilandia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano)pt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduation Program in Nanoscience and Nanobiotechnologypt_BR
dc.description.unidadeFaculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia-
dc.description.unidadeInstituto de Ciências Biológicas (IB)-
dc.description.unidadeDepartamento de Genética e Morfologia (IB GEM)-
dc.description.unidadeFaculdade de Ciências e Tecnologias em Engenharia (FCTE) – Campus UnB Gama-
dc.description.ppgPrograma de Pós-Graduação em Ciências Farmacêuticas-
dc.description.ppgPrograma de Pós-Graduação em Nanociência e Nanobiotecnologia-
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