Título:	Fecal microbiota transplantation ameliorates high‐fat diet‐induced memory impairment in mice
Autor(es):	Pereira, Louise Tavares Garcia Vilela, Wembley Rodrigues Bellozi, Paula Maria Quaglio Engel, Daiane Fátima Paula, Gabriela Cristina de Andrade, Rafael Rocha de Mortari, Márcia Renata Teixeira, Marcus de Melo  Coleine, Claudia Figueiredo, Cláudia Pinto Bem, Andreza Fabro de Amato, Angélica Amorim
ORCID:	https://orcid.org/0000-0001-9467-9891 https://orcid.org/0000-0003-1090-5244 https://orcid.org/0000-0002-8454-5504
Afiliação do autor:	University of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacology University of Brasilia, Institute of Biology, Department of Physiological Sciences University of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacology University of Brasilia, Institute of Biology, Department of Physiological Sciences Federal University of Ouro Preto, School of Pharmacy Universitá della Svizzera Italian Lugano Switzerland, Institute for Research in Biomedicine University of Brasilia, School of Medicine Laboratory of Neuropharmacology, Department of Physiological Sciences, Biology Institute University of Brasilia Federal District Brazil University of Brasilia, Faculty of Medicine, Tropical Medicine Center University of Tuscia, Department of Ecological and Biological Sciences, Viterbo Italy Federal University of Rio de Janeiro, Faculty of Pharmacy, Department of Pharmaceutical Biotechnology University of Brasilia, Institute of Biology, Department of Physiological Sciences Oswaldo Cruz Foundation, Brazilian National Institute of Science and Technology on Neuroimmunomodulation University of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacology
Assunto:	Microbiota intestinal Disbiose Microbiota intestinal - transplante Obesidade
Data de publicação:	Set-2024
Editora:	Wiley
Referência:	PEREIRA, Louise Tavares Garcia et al. Fecal microbiota transplantation ameliorates high‐fat diet‐induced memory impairment in mice. Journal of Neurochemistry, [S. l.], v. 168, n. 9, p. 2893-2907, 2024. DOI: https://doi.org/10.1111/jnc.16156. Disponível em: https://onlinelibrary.wiley.com/doi/10.1111/jnc.16156. Acesso em: 03 ago. 2026.
Abstract:	Gut dysbiosis is linked to metabolic and neurodegenerative diseases and comprises a plausible link between high‐fat diet (HFD) and brain dysfunction. Here we show that gut microbiota modulation by either antibiotic treatment for 5 weeks or a brief 3‐day fecal microbiota transplantation (FMT) regimen from low‐fat (control) diet‐fed mice decreased weight gain, adipose tissue hypertrophy, and glucose intolerance induced by HFD in C57BL/6 male mice. Notably, gut microbiota modulation by FMT completely reversed impaired recognition memory induced by HFD, whereas modulation by antibiotics had less pronounced effect. Improvement in recognition memory by FMT was accompanied by decreased HFD‐induced astrogliosis in the hippocampal cornu ammonis region. Gut microbiome composition analysis indicated that HFD diminished microbiota diversity compared to control diet, whereas FMT partially restored the phyla diversity. Our findings reinforce the role of the gut microbiota on HFD‐induced cognitive impairment and suggest that modulating the gut microbiota may be an effective strategy to prevent metabolic and cognitive dysfunction associated with unfavorable dietary patterns. image
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR) Instituto de Ciências Biológicas (IB) Faculdade de Medicina (FM) Departamento de Ciências Fisiológicas (IB CFS)
DOI:	https://doi.org/10.1111/jnc.16156
Versão da editora:	https://onlinelibrary.wiley.com/doi/10.1111/jnc.16156
Aparece nas coleções:	Artigos publicados em periódicos e afins

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