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dc.contributor.authorPereira, Louise Tavares Garciapt_BR
dc.contributor.authorVilela, Wembley Rodriguespt_BR
dc.contributor.authorBellozi, Paula Maria Quagliopt_BR
dc.contributor.authorEngel, Daiane Fátimapt_BR
dc.contributor.authorPaula, Gabriela Cristina dept_BR
dc.contributor.authorAndrade, Rafael Rocha dept_BR
dc.contributor.authorMortari, Márcia Renatapt_BR
dc.contributor.authorTeixeira, Marcus de Melo pt_BR
dc.contributor.authorColeine, Claudiapt_BR
dc.contributor.authorFigueiredo, Cláudia Pintopt_BR
dc.contributor.authorBem, Andreza Fabro dept_BR
dc.contributor.authorAmato, Angélica Amorimpt_BR
dc.date.accessioned2026-08-03T13:54:05Z-
dc.date.available2026-08-03T13:54:05Z-
dc.date.issued2024-9pt_BR
dc.identifier.citationPEREIRA, Louise Tavares Garcia et al. Fecal microbiota transplantation ameliorates high‐fat diet‐induced memory impairment in mice. Journal of Neurochemistry, [S. l.], v. 168, n. 9, p. 2893-2907, 2024. DOI: https://doi.org/10.1111/jnc.16156. Disponível em: https://onlinelibrary.wiley.com/doi/10.1111/jnc.16156. Acesso em: 03 ago. 2026.pt_BR
dc.identifier.urihttps://doi.org/10.1111/jnc.16156pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/55579-
dc.language.isoengpt_BR
dc.publisherWileypt_BR
dc.rightsAcesso Restritopt_BR
dc.titleFecal microbiota transplantation ameliorates high‐fat diet‐induced memory impairment in micept_BR
dc.typeArtigopt_BR
dc.subject.keywordMicrobiota intestinalpt_BR
dc.subject.keywordDisbiosept_BR
dc.subject.keywordMicrobiota intestinal - transplantept_BR
dc.subject.keywordObesidadept_BR
dc.identifier.doihttps://doi.org/10.1111/jnc.16156pt_BR
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/jnc.16156-
dc.description.abstract1Gut dysbiosis is linked to metabolic and neurodegenerative diseases and comprises a plausible link between high‐fat diet (HFD) and brain dysfunction. Here we show that gut microbiota modulation by either antibiotic treatment for 5 weeks or a brief 3‐day fecal microbiota transplantation (FMT) regimen from low‐fat (control) diet‐fed mice decreased weight gain, adipose tissue hypertrophy, and glucose intolerance induced by HFD in C57BL/6 male mice. Notably, gut microbiota modulation by FMT completely reversed impaired recognition memory induced by HFD, whereas modulation by antibiotics had less pronounced effect. Improvement in recognition memory by FMT was accompanied by decreased HFD‐induced astrogliosis in the hippocampal cornu ammonis region. Gut microbiome composition analysis indicated that HFD diminished microbiota diversity compared to control diet, whereas FMT partially restored the phyla diversity. Our findings reinforce the role of the gut microbiota on HFD‐induced cognitive impairment and suggest that modulating the gut microbiota may be an effective strategy to prevent metabolic and cognitive dysfunction associated with unfavorable dietary patterns. imagept_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9467-9891pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1090-5244pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8454-5504pt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biology, Department of Physiological Sciencespt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biology, Department of Physiological Sciencespt_BR
dc.contributor.affiliationFederal University of Ouro Preto, School of Pharmacypt_BR
dc.contributor.affiliationUniversitá della Svizzera Italian Lugano Switzerland, Institute for Research in Biomedicinept_BR
dc.contributor.affiliationUniversity of Brasilia, School of Medicinept_BR
dc.contributor.affiliationLaboratory of Neuropharmacology, Department of Physiological Sciences, Biology Institute University of Brasilia Federal District Brazilpt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Medicine, Tropical Medicine Centerpt_BR
dc.contributor.affiliationUniversity of Tuscia, Department of Ecological and Biological Sciences, Viterbo Italypt_BR
dc.contributor.affiliationFederal University of Rio de Janeiro, Faculty of Pharmacy, Department of Pharmaceutical Biotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biology, Department of Physiological Sciencespt_BR
dc.contributor.affiliationOswaldo Cruz Foundation, Brazilian National Institute of Science and Technology on Neuroimmunomodulationpt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacologypt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
dc.description.unidadeDepartamento de Ciências Fisiológicas (IB CFS)pt_BR
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