Título:	Perda e reganho de peso, alteração de comorbidades e qualidade de vida após bypass gástrico em Y de Roux para tratamento de pessoas com obesidade : estudo comparativo entre homens e mulheres
Autor(es):	Silva, Luiza Bandeira de Mello Alves da
Orientador(es):	Sousa, João Batista de
Assunto:	Cirurgia bariátrica Bypass gástrico em Y-de-Roux Perda de peso Obesidade
Data de publicação:	8-Jul-2027
Data de defesa:	22-Set-2025
Referência:	SILVA, Luiza Bandeira de Mello Alves da. Perda e reganho de peso, alteração de comorbidades e qualidade de vida após bypass gástrico em Y de Roux para tratamento de pessoas com obesidade: estudo comparativo entre homens e mulheres. 2025. 127 f., il. Tese (Doutorado em Ciências Médicas) — Universidade de Brasília, Brasília, 2025.
Abstract:	Introduction: Obesity is a serious global public health issue, associated with multiple comorbidities and significantly impacting the quality of life of affected individuals. Bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB), has proven effective in promoting weight loss and improving obesity-related clinical conditions. However, outcomes may vary based on individual characteristics such as sex, age, and preoperative body mass index (BMI). Objective: To compare weight loss outcomes, weight regain, control of comorbidities, and perceived quality of life following RYGB between men and women, and to identify which variables influence these outcomes. Methods: This retrospective cohort study included individuals who underwent laparoscopic RYGB between 2013 and 2016. Data were extracted from medical records between 2021 and 2023. Pre- and postoperative clinical and anthropometric variables were analyzed, along with quality of life assessed using a validated questionnaire. Poisson and linear regression models were employed to identify associations between variables. Results: A total of 251 patients were analyzed, comprising 208 women and 43 men. Men had higher pre- and postoperative weights and BMIs, while women showed a greater percentage of excess weight loss (%EWL) and a higher rate of achieving a normal postoperative BMI. Follow-up time and age at the time of surgery were similar between sexes. Men had higher prevalence of diabetes, hypertension, and sleep apnea. Dumping syndrome and absence of hypertension were associated with achieving a normal BMI, regardless of sex. Weight regain >15% from nadir weight was more frequent among men, sedentary individuals, and those with longer follow-up periods. Regain ≥20% of total weight lost (TWL) was associated with sedentarism and younger age, with no significant sex differences. Older patients and those with higher postoperative BMI showed greater medication reduction, more frequently observed in men. Among those who achieved a normal BMI, women had a higher %EWL. Age and BMI influenced various aspects of quality of life, though men more frequently reported improved sexual satisfaction postoperatively. Mean scores of quality-of-life indicators did not significantly differ according to postoperative BMI, normal BMI achievement, %EWL, weight regain, or medication reduction. Conclusion: Men and women exhibit distinct responses to RYGB regarding weight loss and comorbidity improvement. However, perceived quality of life was similar between sexes, suggesting that factors beyond weight loss influence this outcome. These findings highlight the importance of individualized and long-term postoperative follow-up combining clinical and behavioral interventions for bariatric patients.
Unidade Acadêmica:	Faculdade de Medicina (FM)
Informações adicionais:	Tese (doutorado) — Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médicas, 2026.
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências Médicas
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