Título:	Evaluating a venom-bioinspired peptide, NOR-1202, as an antiepileptic treatment in male mice models
Autor(es):	Quintanilha, Maria Varela Torres Gobbo, Giovanna de Azevedo Mello Pinheiro, Gabriela Beserra Souza, Adolfo Carlos Barros de Camargo, Luana Cristina Mortari, Marcia Renata
ORCID:	https://orcid.org/0000-0002-7223-037X https://orcid.org/0000-0002-6849-6001
Afiliação do autor:	University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology
Assunto:	Epilepsia do lobo temporal (ELT) Antiepilépticos Occidentalina-1202 Pilocarpina Ácido caínico Vespa - veneno
Data de publicação:	Ago-2024
Editora:	MDPI
Referência:	QUINTANILHA, Maria Varela Torres et al. Evaluating a venom-bioinspired peptide, NOR-1202, as an antiepileptic treatment in male mice models. Toxins, [S. l.], v. 16, n. 8, 342, 2024. DOI: https://doi.org/10.3390/toxins16080342. Disponível em: https://www.mdpi.com/2072-6651/16/8/342. Acesso em: 4 mai. 2026.
Abstract:	Epilepsy, a neurological disorder characterized by excessive neuronal activity and synchronized electrical discharges, ranks among the most prevalent global neurological conditions. Despite common use, antiepileptic drugs often result in adverse effects and lack effectiveness in controlling seizures in temporal lobe epilepsy (TLE) patients. Recent research explored the potential of occidentalin-1202, a peptide inspired by Polybia occidentalis venom, in safeguarding Wistar rats from chemically induced seizures. The present study evaluated the new analog from occidentalin-1202 named NOR-1202 using acute and chronic pilocarpine-induced models and an acute kainic acid (KA) male mice model. NOR-1202 was administered through the intracerebroventricular (i.c.v.), subcutaneous, or intraperitoneal routes, with stereotaxic procedures for the i.c.v. injection. In the acute pilocarpine-induced model, NOR-1202 (i.c.v.) protected against generalized seizures and mortality but lacked systemic antiepileptic activity. In the KA model, it did not prevent generalized seizures but improved survival. In the chronic TLE model, NOR-1202′s ED50 did not differ significantly from the epileptic or healthy groups regarding time spent in spontaneous recurrent seizures during the five-day treatment. However, the NOR-1202 group exhibited more seizures than the healthy group on the second day of treatment. In summary, NOR-1202 exhibits antiepileptic effects against chemoconvulsant-induced seizures, but no effect was observed when administered systemically.
Unidade Acadêmica:	Instituto de Ciências Biológicas (IB) Departamento de Ciências Fisiológicas (IB CFS)
Programa de pós-graduação:	Programa de Pós-Graduação em Biologia Animal
Licença:	© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
DOI:	https://doi.org/10.3390/toxins16080342
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