Título:	Salivary parameters and dental caries in normoglycemic and hyperglycemic adults : findings from a cross-sectional analysis
Autor(es):	Marques, Rafaella Cristhina Rego Silva, Joana Rodrigues da Alves, Larisse Santos Mendonça Endres, Bruna Leis Pereira-Neto, Pedro Chagas Reis, Letícia Gonçalves Melo, Carlos Daniel Correa de Oliveira Leite, Eduarda Carvalho Alves, Luana Severo Teixeira, Nailê Dame
Afiliação do autor:	University of Brasilia, School of Health Sciences University of Brasilia, School of Health Sciences University of Brasilia, School of Health Sciences University of Brasilia, School of Health Sciences University of Brasilia, School of Health Sciences University of Brasilia, School of Health Sciences University of Brasilia, School of Health Sciences Federal University of Santa Maria, School of Dentistry University of Brasilia, School of Health Sciences
Assunto:	Saliva Hiperglicemia Cárie dentária Cárie radicular Diabetes mellitus tipo 2
Data de publicação:	nov-2025
Editora:	Springer Nature
Referência:	MARQUES, Rafaella Cristhina Rego, et al. Salivary parameters and dental caries in normoglycemic and hyperglycemic adults: findings from a cross-sectional analysis. Clin. Oral Invest., [S. l.], v. 29, 577, 2025. Disponível em: https://link.springer.com/article/10.1007/s00784-025-06666-x. Acesso em: 23 fev. 2026.
Abstract:	Objectives To investigate the association between salivary parameters and the number of coronal and root caries lesions (caries extent), as well as to assess whether glycemic status is influencing this association. Materials and methods This cross-sectional study included dentate adults aged≥35 years. Sociodemographic, behavioral, general and oral health data were collected, as well as salivary parameters, such as flow, pH, buffering capacity, viscoelasticity, and concentration of calcium, glucose, phosphate, and urea. The outcomes were the number of coronal caries (total, active, cavitated) and root caries (total, active, root caries index). Unadjusted and adjusted Poisson regression models were applied to estimate rate ratio (RR) and 95% confidence intervals (CI). Results The average of coronal caries extent was significantly higher in individuals with hyperglycemia. Phosphate stood out as a factor associated with coronal caries, both active lesions and cavitated lesions. Buffering capacity was also associated with coronal cavitated caries lesion. Regarding root caries, pH and calcium were associated with the total number of root lesions while pH and urea were associated with the number of active root lesions. Glucose levels and viscoelasticity were also associated with root caries. Conclusions Qualitative salivary parameters were associated with the number of caries lesions differently for coronal and root caries, even after adjusting for the glycemic status. Clinical relevance Association between caries and hyperglycemia should consider salivary parameters beyond flow, along with both caries lesion extent and activity outcomes.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Odontologia (FS ODT)
Programa de pós-graduação:	Programa de Pós-Graduação em Odontologia
Licença:	Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
DOI:	https://doi.org/10.1007/s00784-025-06666-x
Versão da editora:	https://link.springer.com/article/10.1007/s00784-025-06666-x
Agência financiadora:	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) e Empresa Brasileira de Serviços Hospitalares (Ebserh).
Aparece nas coleções:	Artigos publicados em periódicos e afins

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