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dc.contributor.authorRodrigues, Aline de Queiroz-
dc.contributor.authorCarvalho, Guilherme G.-
dc.contributor.authorPiau, Tathyana Benetis-
dc.contributor.authorVeiga, Fabiane H.-
dc.contributor.authorSouza, Paulo E. N.-
dc.contributor.authorMoreira, Daniel C.-
dc.contributor.authorTierno, Natalia I. Z.-
dc.contributor.authorMacedo, Yamara A.-
dc.contributor.authorAmaral, Maria Eduarda B.-
dc.contributor.authorNakagawa, Hitomi M.-
dc.contributor.authorGoulart, Jair Trapé-
dc.contributor.authorPaulini, Fernanda-
dc.date.accessioned2026-02-06T17:22:07Z-
dc.date.available2026-02-06T17:22:07Z-
dc.date.issued2025-12-
dc.identifier.citationRODRIGUES, Aline de Queiroz, et. al. Impact of oxidative stress on female reproductive parameters: an analysis of systemic and follicular biomarkers. JBRA Assist Reprod., [S. l.], v. 29, n. 4, 2025. DOI: https://doi.org/10.5935/1518-0557.20250047. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC12695009/. Acesso em: 06 fev. 2026.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/53942-
dc.language.isoengpt_BR
dc.publisherPMCIDpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleImpact of oxidative stress on female reproductive parameters : an analysis of systemic and follicular biomarkerspt_BR
dc.typeArtigopt_BR
dc.subject.keywordFertilidadept_BR
dc.subject.keywordReprodução assistidapt_BR
dc.subject.keywordEquilíbrio redoxpt_BR
dc.subject.keywordBiomarcadores oxidativospt_BR
dc.subject.keywordParâmetro reprodutivopt_BR
dc.rights.licenseThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.pt_BR
dc.identifier.doihttps://doi.org/10.5935/1518-0557.20250047pt_BR
dc.relation.publisherversionhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12695009/pt_BR
dc.description.abstract1Objective: To examine the relationship between oxidative stress markers and reproductive parameters in women undergoing assisted reproductive treatments, focusing on the interaction between demographic, oxidative, and reproductive factors. Methods: A total of 49 patients with a mean age of 36.0±3.5years were evaluated. Biomarkers analyzed included reduced glutathione (GSH), disulfide glutathione (GSSG), total glutathione (tGSH), the GSSG/GSH ratio, reactive oxygen species (ROS), and reactive nitrogen species (RNS). Blood and follicular fluid samples were collected and analyzed, correlating these markers with variables such as antral follicle count (AFC), oocytes retrieved, mature oocytes, blastocyst formation, and pregnancy rates. Results: The results showed that AFC is a key marker of ovarian reserve, correlating positively with the number of oocytes retrieved and mature oocytes. Age significantly influenced antioxidant markers in both blood and follicular fluid, with a decline in antioxidant capacity linked to aging. In follicular fluid, higher GSSG levels correlated with the number of oocytes retrieved, indicating increased metabolic activity and ROS generation, thus raising oxidative burden during ovarian stimulation. Additionally, GSH and tGSH levels in blood negatively correlated with mature oocytes, suggesting greater antioxidant consumption during elevated metabolic demand. Conclusions: Glutathione is a robust and clinically promising redox biomarker for female fertility, evidencing strong correlations between systemic and follicular redox markers. Advancing age and repeated ovarian stimulation were shown to compromise antioxidant capacity, negatively impacting reproductive outcomes. Establishing reference values, particularly for the GSH/GSSG ratio, may enable its use as a prognostic tool, while the quantification of ROS and RNS could support personalized interventions and ovarian stimulation protocols.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3548-4119pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0005-2936-2149pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0737-1077pt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Physiological Sciencespt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Physiological Sciencespt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Physiological Sciencespt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Health Sciences and Technologiespt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Physics, Laboratory of Electron Paramagnetic Resonancept_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Medicine, Morphology and Applied Immunology Research Centerpt_BR
dc.contributor.affiliationMaternal and Child Hospital of Brasilia Dr. Antonio Lisboa, Assisted Reproduction Sectorpt_BR
dc.contributor.affiliationMaternal and Child Hospital of Brasilia Dr. Antonio Lisboa, Assisted Reproduction Sectorpt_BR
dc.contributor.affiliationGenesis - Human Reproduction Assistance Centerpt_BR
dc.contributor.affiliationGenesis - Human Reproduction Assistance Centerpt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Physiological Sciencespt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Physiological Sciencespt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Ciências Fisiológicas (IB CFS)pt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
dc.description.unidadeInstituto de Física (IF)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Biologia Animal-
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