Título:	Potential single nucleotide polymorphisms markers for radiation dermatitis in head and neck cancer patients : a meta-analysis
Autor(es):	Aguiar, Beatriz Regina Lima Ferreira, Elaine Barros Normando, Ana Gabriela Costa Dias, Sabrina dos Santos Guerra, Eliete Neves Silva Reis, Paula Elaine Diniz
ORCID:	https://orcid.org/0000-0003-0428-834X https://orcid.org/0000-0002-0307-4991 https://orcid.org/0000-0001-7685-473X
Afiliação do autor:	University of Brasilia, School of Health Sciences, Health Science Graduate Program University of Brasilia, School of Health Sciences, Health Science Graduate Program University of Brasilia, School of Health Sciences, Nursing Department University of Campinas, Piracicaba Dental School, Oral Diagnosis Department Superior School of Health Sciences, Brasília University of Brasilia, School of Health Sciences, Laboratory of Oral Histopathology University of Brasilia, School of Health Sciences, Nursing Department
Assunto:	Marcadores genéticos Polimorfismo (Genética) Radiodermatite Radioterapia Cabeça - câncer Pescoço - câncer
Data de publicação:	26-abr-2024
Editora:	Springer
Referência:	AGUIAR, Beatriz Regina Lima et al. Potential Single Nucleotide Polymorphisms markers for radiation dermatitis in head and neck cancer patients: a meta-analysis. Strahlenther Onkol, [S. l.], v. 200, p. 568–582, 2024. DOI: https://doi.org/10.1007/.s00066-024-02237-3.
Abstract:	Purpose To identify potential Single Nucleotide Polymorphisms (SNPs) of susceptibility for the development of acute radiation dermatitis in head and neck cancer patients, and also to verify the association between SNPs and the severity of RD. Methods This systematic review was reported according to the PRISMA guideline. The proportion meta-analysis was performed to identify the prevalence of genetic markers by geographical region and radiation dermatitis severity. The meta-analysis was performed to verify the association between genetic markers and RD severity. The certainty of the evidence was assessed by GRADE. Results Thirteen studies were included. The most prevalent SNPs were XRCC3 (rs861639) (36%), TGFβ1 (rs1800469) (35%), and RAD51 (rs1801321) (34%). There are prevalence studies in Europe and Asia, with a similar prevalence for all SNPs (29–40%). The prevalence was higher in patients who developed radiation dermatitis ≤2 for any subtype of genes (75–76%). No SNP showed a statistically significant association with very low certainty of evidence. Conclusion The most prevalent SNPs may be predictors of acute RD. The analysis of SNP before starting radiation therapy may be a promising method to predict the risk of developing radiation dermatitis and allow radiosensitive patients to have a customized treatment. This current review provides new research directions.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências da Saúde
DOI:	https://doi.org/10.1007/.s00066-024-02237-3
Versão da editora:	https://link.springer.com/article/10.1007/s00066-024-02237-3
Aparece nas coleções:	Artigos publicados em periódicos e afins

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