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dc.contributor.authorAguiar, Beatriz Regina Lima-
dc.contributor.authorFerreira, Elaine Barros-
dc.contributor.authorNormando, Ana Gabriela Costa-
dc.contributor.authorDias, Sabrina dos Santos-
dc.contributor.authorGuerra, Eliete Neves Silva-
dc.contributor.authorReis, Paula Elaine Diniz-
dc.date.accessioned2026-01-30T15:27:02Z-
dc.date.available2026-01-30T15:27:02Z-
dc.date.issued2024-04-26-
dc.identifier.citationAGUIAR, Beatriz Regina Lima et al. Potential Single Nucleotide Polymorphisms markers for radiation dermatitis in head and neck cancer patients: a meta-analysis. Strahlenther Onkol, [S. l.], v. 200, p. 568–582, 2024. DOI: https://doi.org/10.1007/.s00066-024-02237-3.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/53819-
dc.language.isoengpt_BR
dc.publisherSpringerpt_BR
dc.rightsAcesso Restritopt_BR
dc.titlePotential single nucleotide polymorphisms markers for radiation dermatitis in head and neck cancer patients : a meta-analysispt_BR
dc.typeArtigopt_BR
dc.subject.keywordMarcadores genéticospt_BR
dc.subject.keywordPolimorfismo (Genética)pt_BR
dc.subject.keywordRadiodermatitept_BR
dc.subject.keywordRadioterapiapt_BR
dc.subject.keywordCabeça - câncerpt_BR
dc.subject.keywordPescoço - câncerpt_BR
dc.identifier.doihttps://doi.org/10.1007/.s00066-024-02237-3pt_BR
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00066-024-02237-3pt_BR
dc.description.abstract1Purpose To identify potential Single Nucleotide Polymorphisms (SNPs) of susceptibility for the development of acute radiation dermatitis in head and neck cancer patients, and also to verify the association between SNPs and the severity of RD. Methods This systematic review was reported according to the PRISMA guideline. The proportion meta-analysis was performed to identify the prevalence of genetic markers by geographical region and radiation dermatitis severity. The meta-analysis was performed to verify the association between genetic markers and RD severity. The certainty of the evidence was assessed by GRADE. Results Thirteen studies were included. The most prevalent SNPs were XRCC3 (rs861639) (36%), TGFβ1 (rs1800469) (35%), and RAD51 (rs1801321) (34%). There are prevalence studies in Europe and Asia, with a similar prevalence for all SNPs (29–40%). The prevalence was higher in patients who developed radiation dermatitis ≤2 for any subtype of genes (75–76%). No SNP showed a statistically significant association with very low certainty of evidence. Conclusion The most prevalent SNPs may be predictors of acute RD. The analysis of SNP before starting radiation therapy may be a promising method to predict the risk of developing radiation dermatitis and allow radiosensitive patients to have a customized treatment. This current review provides new research directions.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0428-834Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0307-4991pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7685-473Xpt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Health Science Graduate Programpt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Health Science Graduate Programpt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Nursing Departmentpt_BR
dc.contributor.affiliationUniversity of Campinas, Piracicaba Dental School, Oral Diagnosis Departmentpt_BR
dc.contributor.affiliationSuperior School of Health Sciences, Brasíliapt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Laboratory of Oral Histopathologypt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Nursing Departmentpt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências da Saúdept_BR
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