Título:	KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma : a systematic review
Autor(es):	Santos, Marcos Ezequiel da Silva Abreu, Anna Karolina de Carvalho Silva, Fabio Willian Martins da Ferreira, Elaine Barros Reis, Paula Elaine Diniz dos Ramos, Doralina do Amaral Rabello
ORCID:	https://orcid.org/0000-0002-5282-7785 https://orcid.org/0000-0001-6953-6901 https://orcid.org/0000-0001-6654-5239 https://orcid.org/0000-0003-0428-834X https://orcid.org/0000-0002-9782-3366 https://orcid.org/0000-0002-6272-6558
Afiliação do autor:	University of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancer University of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancer University of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancer University of Brasília, School of Health Sciences, Interdisciplinary Laboratory of Applied Research on Clinical Practice in Oncology University of Brasília, School of Health Sciences, Interdisciplinary Laboratory of Applied Research on Clinical Practice in Oncology University of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancer
Assunto:	Metiltransferases Carcinoma espinocelular Câncer de cabeça e pescoço Revisão sistemática
Data de publicação:	15-Dez-2023
Editora:	Wiley
Referência:	SANTOS, Marcos Ezequiel da Silva. KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma: a systematic review. Head & Neck, v. 46, n. 2, p. 417-434, 2023. DOI: https://doi.org/10.1002/hed.27597. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/hed.27597. Acesso em: 03 jul. 2025.
Abstract:	Background: The involvement of the KMT2 methyltransferase family in the pathogenesis of head and neck squamous cell carcinoma (HNSCC) remains elusive. Method: This study adhered to the PRISMA guidelines, employing a search strategy in the LIVIVO, PubMed, Scopus, Embase, Web of Science, and Google Scholar databases. The methodological quality of the studies was assessed by the Joanna Briggs Institute. Results: A total of 33 studies involving 4294 individuals with HNSCC were included in this review. The most important alteration was the high mutational frequency in the KMT2C and KMT2D genes, with reported cooccurrence. The expression of the KMT2D gene exhibited considerable heterogeneity across the studies, while limited data was available for the remaining genes. Conclusions: KMT2C and KMT2D genes seem to have tumor suppressor activities, with involvement of cell cycle inhibitors, regulating different pathways that can lead to tumor progression, disease aggressiveness, and DNA damage accumulation.
Unidade Acadêmica:	Faculdade de Medicina (FM) Faculdade de Ciências da Saúde (FS) Departamento de Enfermagem (FS ENF)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências Médicas Programa de Pós-Graduação em Enfermagem
Licença:	This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. © 2023 The Authors. Head & Neck published by Wiley Periodicals LLC.
DOI:	https://doi.org/10.1002/hed.27597
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