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dc.contributor.authorSantos, Marcos Ezequiel da Silva-
dc.contributor.authorAbreu, Anna Karolina de Carvalho-
dc.contributor.authorSilva, Fabio Willian Martins da-
dc.contributor.authorFerreira, Elaine Barros-
dc.contributor.authorReis, Paula Elaine Diniz dos-
dc.contributor.authorRamos, Doralina do Amaral Rabello-
dc.date.accessioned2025-09-18T15:07:24Z-
dc.date.available2025-09-18T15:07:24Z-
dc.date.issued2023-12-15-
dc.identifier.citationSANTOS, Marcos Ezequiel da Silva. KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma: a systematic review. Head & Neck, v. 46, n. 2, p. 417-434, 2023. DOI: https://doi.org/10.1002/hed.27597. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/hed.27597. Acesso em: 03 jul. 2025.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/52463-
dc.language.isoengpt_BR
dc.publisherWileypt_BR
dc.rightsAcesso Abertopt_BR
dc.titleKMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma : a systematic reviewpt_BR
dc.typeArtigopt_BR
dc.subject.keywordMetiltransferasespt_BR
dc.subject.keywordCarcinoma espinocelularpt_BR
dc.subject.keywordCâncer de cabeça e pescoçopt_BR
dc.subject.keywordRevisão sistemáticapt_BR
dc.rights.licenseThis is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. © 2023 The Authors. Head & Neck published by Wiley Periodicals LLC.pt_BR
dc.identifier.doihttps://doi.org/10.1002/hed.27597pt_BR
dc.description.abstract1Background: The involvement of the KMT2 methyltransferase family in the pathogenesis of head and neck squamous cell carcinoma (HNSCC) remains elusive. Method: This study adhered to the PRISMA guidelines, employing a search strategy in the LIVIVO, PubMed, Scopus, Embase, Web of Science, and Google Scholar databases. The methodological quality of the studies was assessed by the Joanna Briggs Institute. Results: A total of 33 studies involving 4294 individuals with HNSCC were included in this review. The most important alteration was the high mutational frequency in the KMT2C and KMT2D genes, with reported cooccurrence. The expression of the KMT2D gene exhibited considerable heterogeneity across the studies, while limited data was available for the remaining genes. Conclusions: KMT2C and KMT2D genes seem to have tumor suppressor activities, with involvement of cell cycle inhibitors, regulating different pathways that can lead to tumor progression, disease aggressiveness, and DNA damage accumulation.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5282-7785pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6953-6901pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6654-5239pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0428-834Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9782-3366pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6272-6558pt_BR
dc.contributor.affiliationUniversity of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancerpt_BR
dc.contributor.affiliationUniversity of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancerpt_BR
dc.contributor.affiliationUniversity of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancerpt_BR
dc.contributor.affiliationUniversity of Brasília, School of Health Sciences, Interdisciplinary Laboratory of Applied Research on Clinical Practice in Oncologypt_BR
dc.contributor.affiliationUniversity of Brasília, School of Health Sciences, Interdisciplinary Laboratory of Applied Research on Clinical Practice in Oncologypt_BR
dc.contributor.affiliationUniversity of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancerpt_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Enfermagem (FS ENF)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências Médicaspt_BR
dc.description.ppgPrograma de Pós-Graduação em Enfermagempt_BR
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