Título :	A greener approach for the synthesis of pyrido[2,3-d] pyrimidine derivatives in glycerol under microwave heating
Autor :	Martinho, Luan Alves Andrade, Carlos Kleber Zago de
metadata.dc.identifier.orcid:	https://orcid.org/0000-0001-6658-5847 https://orcid.org/0000-0003-0798-9133
metadata.dc.contributor.affiliation:	Universidade de Brasília, Instituto de Química, Laboratorio de Química Metodologica e Orgânica Sintética (LaQMOS) Universidade de Brasília, Instituto de Química, Laboratorio de Química Metodologica e Orgânica Sintética (LaQMOS)
Assunto::	Solventes orgânicos Pirido[2,3-d]pirimidinas
Fecha de publicación :	22-mar-2022
Editorial :	Wiley
Citación :	MARTINHO, Luan Alves; ANDRADE, Carlos Kleber Zago de. A greener approach for the synthesis of pyrido[2,3-d] pyrimidine derivatives in glycerol under microwave heating. Journal of Heterocyclic Chemistry, [S. l.], v. 59, n. 8, 2022. DOI: https://doi.org/10.1002/jhet.4483. Disponível em: https://onlinelibrary.wiley.com/doi/full/10.1002/jhet.4483. Acesso em: 06 jun. 2025.
Abstract:	Herein, we report the multicomponent synthesis of pyrido[2,3-d]pyrimidine derivatives from 6-aminouracil, aromatic aldehydes, and malononitrile in glycerol as a green solvent under microwave heating. This methodology shows several advantages: catalyst-free synthesis, up to 90% yield, operational simplicity, short reaction times, easy work-up procedure, and a greener approach compared with other methods reported in the literature.
metadata.dc.description.unidade:	Instituto de Química (IQ)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Química
DOI:	https://doi.org/10.1002/jhet.4483
metadata.dc.relation.publisherversion:	https://onlinelibrary.wiley.com/doi/full/10.1002/jhet.4483
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