Título:	Hyaluronic acid to manage radiotoxicities in gynecological cancer patients : a scoping review
Autor(es):	Ribeiro, Letícia da Silva Silveira, Renata Cristina de Campos Pereira Vasques, Christiane Inocêncio Menêses, Amanda Gomes de Reis, Paula Elaine Diniz dos Ferreira, Elaine Barros
E-mail do autor:	mailto:elainebf@unb.br
ORCID:	https://orcid.org/0009-0000-7244-7213 https://orcid.org/0000-0002-2883-3640 https://orcid.org/0000-0001-9586-9486 https://orcid.org/0000-0002-8658-7505 https://orcid.org/0000-0002-9782-3366 https://orcid.org/0000-0003-0428-834X
Afiliação do autor:	Universidade de Brasília, Faculdade de Ciências da Saúde, Departamento de Enfermagem Universidade de São Paulo Universidade de Brasília, Faculdade de Ciências da Saúde, Departamento de Enfermagem Universidade de Brasília, Faculdade de Ciências da Saúde, Departamento de Enfermagem Universidade de Brasília, Faculdade de Ciências da Saúde, Departamento de Enfermagem Universidade de Brasília, Faculdade de Ciências da Saúde, Departamento de Enfermagem
Assunto:	Ácido hialurônico Radioterapia Braquiterapia Neoplasias dos genitais femininos
Data de publicação:	18-Jun-2024
Editora:	Springer Nature
Referência:	RIBEIRO, Letícia da Silva et. al. Hyaluronic acid to manage radiotoxicities in gynecological cancer patients: a scoping review. Support Care Cancer, v. 32, art. 439, 2024. DOI 10.1007/s00520-024-08614-z. Disponível em: https://link.springer.com/article/10.1007/s00520-024-08614-z. Acesso em: 10 mar. 2025.
Abstract:	Purpose This study aimed to map the use of hyaluronic acid (HA) in preventing and controlling radiotoxicity in women with gynecological cancer undergoing radiotherapy. Methods We conducted a scoping review of eight electronic databases: CINAHL, Cochrane CENTRAL, LILACS, PubMed, Scopus, Embase, LIVIVO, and the Web of Science Core Collection. In addition, a grey literature search was performed using Google Scholar and ProQuest Dissertations & Theses Global. A manual search was also identifed additional references. The search was conducted on May 18, 2023. We included primary studies, reviews, and guidelines that discussed the use of HA to prevent and manage the toxicities resulting from gynecological radiotherapy. Results Eighteen studies were included in this scoping review, published between 2009 and 2022. There was heterogeneity in the use of HA, particularly in the method of application (moisturizing gel, vaginal ovules, spacer gel, and bladder instillations). Furthermore, the radiotoxicities varied among studies, encompassing, among others, vaginal atrophy, dryness, dyspareunia, telangiectasis, adhesions, vaginal stenosis, bleeding, hematuria, and bladder issues. Most studies addressed the potential benefts of HA in managing the signs and symptoms resulting from radiotherapy. Conclusion HA has been utilized in clinical practice, in various formulations, for managing signs and symptoms in patients with gynecological cancer undergoing radiotherapy. However, further studies are necessary to thoroughly investigate the most efective method of HA application and its efectiveness in managing radiotoxicity.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Enfermagem (FS ENF)
Licença:	Embargo requerido pela revista de 12 meses a partir da data da publicação.
DOI:	https://doi.org/10.1007/s00520-024-08614-z
Versão da editora:	https://link.springer.com/article/10.1007/s00520-024-08614-z
Aparece nas coleções:	Artigos publicados em periódicos e afins

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