Título:	Avaliação epidemiológica de intoxicações por paracetamol no Distrito Federal entre 2013 e 2018
Autor(es):	Carvalho, Aline Fernandes de
Orientador(es):	Mello, Mauricio Homem de
Assunto:	Paracetamol Medicamentos Medicamentos - utilização Intoxicações exógenas
Data de publicação:	6-Ago-2024
Data de defesa:	29-Dez-2022
Referência:	CARVALHO, Aline Fernandes de. Avaliação epidemiológica de intoxicações por paracetamol no Distrito Federal entre 2013 e 2018. 2022. 52 f., il. Dissertação (Mestrado em Ciências Farmacêuticas) — Universidade de Brasília, Brasília, 2022.
Abstract:	Paracetamol isthe most widely used over-the-counter(OTC) analgesic agent in the world. It is the drug most involved in cases of poisoning in several countries. Acetaminophen poisoning is common and potentially fatal. It is the most prevalent cause of acute liver failure in the world. In Brazil, paracetamol is one of the most prevalent agents in cases of drug intoxication. At the Center for Information and Toxicological Assistance of the Federal District (CIATox-DF) it was the main analgesic involved in cases of poisoning registered between 2011 and 2016. The high incidence of paracetamol poisoning in Brazil and in the world constitutes a public health problem. Studies on this condition are scarce in Brazil and in the Federal District (DF). Therefore, it is necessary to evaluate this event in the Federal District. The present study aimed to determine the epidemiological profile (age, gender, evolutionary circumstance) of reported poisonings associated with paracetamol in the Federal District between 2013 and 2018. Therefore, it was necessary to analyze the CIATox-DF databases, from SINAN (Notifiable Diseases Notification System) and the SIM (Mortality Information System). In CIATox, the primary source of data were the electronic medical recordsthat record the clinical history of the intoxication, the toxic agent involved, the patient's clinical evolution and the evolution of cases of poisoning treated. In SINAN, the primary source of data was the specific individual notification form for the exogenous intoxication injury (Annex I) which records the general data of the injury (agent, circumstance, evolution) the notifying unit and general data of the patient. In SIM, the primary source of data was the Death Document (DC). During the study period, 292 cases of intoxication by the agent reported to SINAN and 301 cases reported to CIATox-DF were registered. Cases registered at SINAN and CIATox-DF showed different epidemiological profiles. At SINAN, the most affected age group was between 15 and 29 years old and the most prevalent circumstance was suicide attempt. While in CIATox-DF, accidental intoxications in children were predominant. There were a total of 33 deaths recorded in the SIM for this condition and women were more affected. The results were limited by the quality of the records. we suspect that there is underreporting of the correct cause of death, because the ICD-10 (International Classification of Diseases) included in the DO probably refers to acute exposures and/or more severe cases, with better investigations. SINAN data show that more serious intoxications were reported in this database. but even so, it was possible to identify the relevance of suicide cases using over-the-counter drugs such as paracetamol. It is clear that paracetamol poisoning is a public health problem in Brazil and worldwide. Measures are needed to promote the rational use of medicines. Studies that portray intentional and fatal intoxications with drugs can help in the development and implementation of health programs to prevent this event.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR)
Informações adicionais:	Dissertação (mestrado) — Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas, 2022.
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências Farmacêuticas
Aparece nas coleções:	Teses, dissertações e produtos pós-doutorado

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