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Title: Influence of in vitro micropropagation on lycorine biosynthesis and anticholinesterase activity in Hippeastrum goianum
Authors: Costa, Gabriella Gusmão Pereira da
Silva, Cristian Aldemar Gasca
Gomes, João Victor Dutra
Torres, Amanda Gomes
Santos, Izulmé Rita Imaculada
Almeida, Fabrício Tavares Cunha de
Fagg, Christopher William
Simeoni, Luiz Alberto
Silveira, Dâmaris
Gomes-Copeland, Kicia Karinne Pereira
metadata.dc.identifier.orcid: http://orcid.org/0000-0002-3393-5609
http://orcid.org/0000-0003-4392-4230
http://orcid.org/0000-0001-6098-3852
http://orcid.org/0000-0001-9599-4578
http://orcid.org/0000-0002-1503-1497
http://orcid.org/0000-0002-0531-7483
http://orcid.org/0000-0001-6072-7832
http://orcid.org/0000-0003-3401-290X
http://orcid.org/0000-0003-1851-5224
http://orcid.org/0000-0003-3539-2916
Assunto:: Alcalóides
Biossíntese
Cromatografia a líquido
Licorina
Espectrometria de massa
Issue Date: 2019
Publisher: Sociedade Brasileira de Farmacognosia
Citation: COSTA, Gabriella Gusmão Pereira da et al. Influence of in vitro micropropagation on lycorine biosynthesis and anticholinesterase activity in Hippeastrum goianum. Revista Brasileira de Farmacognosia, v. 29, n. 2, p. 262-265, 2019. DOI: https://doi.org/10.1016/j.bjp.2019.02.001. Disponível em: http://scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000200262. Acesso em: 23 jan.2020.
Abstract: Hippeastrum goianum (Ravenna) Meerow, Amaryllidaceae, is an endemic species from the Cerrado, Brazil; there are only few studies about its chemistry or biological activity. This study aimed to investigate the occurrence of lycorine in extracts from in vitro H. goianum plantlets, as well as evaluate a possible inhibition of acetylcholinesterase. The ethanol extract of plantlets produced by in vitro seed germination and micropropagation of bulblets was obtained from seedlings from in vitro germination, while the ethanol extract micropropagtion of bulblets was obtained from a subculture of those seedlings. The presence of lycorine was detected in only in the micropropagation of bulblets. The micropropagation of bulblets was more active than the plantlets produced by in vitro seed germination, with an IC50 of 114.8 ± 0.95 µg/ml and IC50 386.00 ± 0.97 µg/ml, respectively. These results showed that both in vitro germination and micropropagation of H. goianum can lead to the biosynthesis of lycorine. Moreover, the micropropagation led to improved anticholinesterase activity.
Licença:: This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
DOI: https://doi.org/10.1016/j.bjp.2019.02.001
Appears in Collections:FAR - Artigos publicados em periódicos
FCE-FAR - Artigos publicados em periódicos

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