Título:	Cyclophosphamide administration routine in autoimmune rheumatic diseases : a review
Outros títulos:	Rotina de administração de ciclofosfamida em doenças autoimunes reumáticas : uma revisão
Autor(es):	Teles, Kaian Amorim Medeiros-Souza, Patricia Lima, Francisco Aires Correa Araújo, Bruno Gedeon de Lima, Rodrigo Aires Correa
Assunto:	Ciclofosfamida Antieméticos Quimioterapia Cistite
Data de publicação:	Dez-2017
Editora:	Sociedade Brasileira de Reumatologia
Referência:	TELES, Kaian Amorim et al. Cyclophosphamide administration routine in autoimmune rheumatic diseases: a review. Revista Brasileira de Reumatologia, São Paulo, v. 57, n. 6, p. 596-604, out./dez. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000600596&lng=en&nrm=iso>. Acesso em: 30 jan. 2018. doi: http://dx.doi.org/10.1016/j.rbre.2016.09.008. ________________________________________________________________________________________________________________________________ TELES, Kaian Amorim et al. Rotina de administração de ciclofosfamida em doenças autoimunes reumáticas: uma revisão. Revista Brasileira de Reumatologia, São Paulo, v. 57, n. 6, p. 596-604, nov./dez. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000600596&lng=en&nrm=iso>. Acesso em: 30 jan. 2018. doi: http://dx.doi.org/10.1016/j.rbre.2016.09.008.
Abstract:	Cyclophosphamide is an alkylating agent widely used for the treatment of malignant neoplasia and which can be used in the treatment of multiple rheumatic diseases. Medication administration errors may lead to its reduced efficacy or increased drug toxicity. Many errors occur in the administration of injectable drugs. The present study aimed at structuring a routine for cyclophosphamide use, as well as creating a document with pharmacotherapeutic guidelines for the patient. The routine is schematized in three phases: pre-chemotherapy, administration of cyclophosphamide, and post-chemotherapy, taking into account the drugs to be administered before and after cyclophosphamide in order to prevent adverse effects, including nausea and hemorrhagic cystitis. Adverse reactions can alter laboratory tests; thus, this routine included clinical management for changes in white blood cells, platelets, neutrophils, and sodium, including cyclophosphamide dose adjustment in the case of kidney disease. Cyclophosphamide is responsible for other rare - but serious - side effects, for instance, hepatotoxicity, severe hyponatremia and heart failure. Other adverse reactions include hair loss, amenorrhea and menopause. In this routine, we also entered guidelines to post-chemotherapy patients. The compatibility of injectable drugs with the vehicle used has been described, as well as stability and infusion times. The routine aimed at the rational use of cyclophosphamide, with prevention of adverse events and relapse episodes, factors that may burden the health care system.
Licença:	Revista Brasileira de Reumatologia - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way (CC BY NC ND 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000600596&lng=en&nrm=iso. Acesso em: 30 jan. 2018.
DOI:	http://dx.doi.org/10.1016/j.rbre.2016.09.008
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