Título:	Ação neuroprotetora da sonata de Mozart na aprendizagem e memória de ratos expostos à hipóxia cerebral
Autor(es):	Costa, Larice Feitosa
Orientador(es):	Ferreira, Vania Maria Moraes
Assunto:	Aprendizagem - rato Isquemia cerebral Memória Música - instrução e estudo
Data de publicação:	24-Out-2016
Data de defesa:	14-Jun-2016
Referência:	COSTA, Larice Feitosa. Ação neuroprotetora da sonata de Mozart na aprendizagem e memória de ratos expostos à hipóxia cerebral. 2016. 44 f., il. Dissertação (Mestrado em Ciências do Comportamento)—Universidade de Brasília, Brasília, 2016.
Abstract:	The hypoxic ischemic (HI) brain triggers a cascade of biochemical events that may lead to extensive cell death, leading to cognitive and behavioral deficits. Exposure to music, in turn, has been proposed as beneficial neuroprotective effect during brain development and enhance the capacity of learning and memory in rats. However, the responses produced by these events appear to be dependent on the stage of development of the brain. Thus, the aim of this study was to investigate the neuroprotective effect of Mozart's Sonata in learning and memory in rats with and without HI, at different stages of development of the central nervous system. To this end, we used female Wistar rats (n = 48) evaluated in a step-down inhibitory avoidance task, which was divided into three stages: training, learning/short-term memory (STM) and long-term memory (LTM). HI was induced in rats with sodium nitrite at 3 months of age. It was used 6 experimental groups of rats (n = 8/group), divided into G1 (control), G2 (control with HI), G3 (acute music), G4 (acute music and HI), G5 (chronic music), G6 (chronic music and HI). The results showed that the control animals, when assessed in sequential manner to complete 1, 2, 3 and 4 months of age showed a response that was progressively increased when rats were exposed once a month with Mozart Sonata for 4h/day/4 days. This response was maintained even with the potential damage produced by sodium nitrite. The most significant effects of this experimental stage was at 3 and 4 months old. Conversely, when exposed 4h/day/4 months, the animals only showed responses at 4 months age, which was not maintained against damage caused by HI. In summary, the data could infer that exposure to Mozart's Sonata appears to be an important factor for stimulating neuronal plasticity, as when exposed acutely it was revealed answers suggestive of learning and memory even after induced HI injury, while chronic exposure showed no neuroprotective effect against injury. These findings seem to demonstrate the possibility of using an important tool to neuroplasticity, relevant to the development of the brain and neurological rehabilitation.
Unidade Acadêmica:	Instituto de Psicologia (IP) Departamento de Processos Psicológicos Básicos (IP PPB)
Informações adicionais:	Dissertação (mestrado)—Universidade de Brasília, Instituto de Psicologia, Departamento de Processos Psicológicos Básicos, Programa de Pós-Graduação em Ciências do Comportamento, 2016.
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências do Comportamento
Licença:	A concessão da licença deste item refere-se ao termo de autorização impresso assinado pelo autor com as seguintes condições: Na qualidade de titular dos direitos de autor da publicação, autorizo a Universidade de Brasília e o IBICT a disponibilizar por meio dos sites www.bce.unb.br, www.ibict.br, http://hercules.vtls.com/cgi-bin/ndltd/chameleon?lng=pt&skin=ndltd sem ressarcimento dos direitos autorais, de acordo com a Lei nº 9610/98, o texto integral da obra disponibilizada, conforme permissões assinaladas, para fins de leitura, impressão e/ou download, a título de divulgação da produção científica brasileira, a partir desta data.
DOI:	http://dx.doi.org/10.26512/2016.06.D.21616
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