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ARTIGO_DifferentialMetabolismMycoplasma.pdf82,55 kBAdobe PDFVisualizar/Abrir
Título: Differential metabolism of Mycoplasma species as revealed by their genomes
Autor(es): Arraes, Fabrício Barbosa Monteiro
Carvalho, Maria José Albuquerque de
Maranhão, Andréa Queiroz
Brígido, Marcelo de Macedo
Pedrosa, Fábio O.
Felipe, Maria Sueli Soares
Assunto: Micoplasmas
Molicuttes
Bactérias patogênicas
Data de publicação: 2007
Editora: Sociedade Brasileira de Genética
Referência: ARRAES, Fabrício B. M. et al. Differential metabolism of Mycoplasma species as revealed by their genomes. Genetics and Molecular Biology, São Paulo, v. 30, n. 1, 2007. Suplemento. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000200004&lng=pt&nrm=iso&tlng=en>. Acesso em: 21 mar. 2013. http://dx.doi.org/10.1590/S1415-47572007000200004.
Resumo: The annotation and comparative analyses of the genomes of Mycoplasma synoviae and Mycoplasma hyopneumonie, as well as of other Mollicutes (a group of bacteria devoid of a rigid cell wall), has set the grounds for a global understanding of their metabolism and infection mechanisms. According to the annotation data, M. synoviae and M. hyopneumoniae are able to perform glycolytic metabolism, but do not possess the enzymatic machinery for citrate and glyoxylate cycles, gluconeogenesis and the pentose phosphate pathway. Both can synthesize ATP by lactic fermentation, but only M. synoviae can convert acetaldehyde to acetate. Also, our genome analysis revealed that M. synoviae and M. hyopneumoniae are not expected to synthesize polysaccharides, but they can take up a variety of carbohydrates via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). Our data showed that these two organisms are unable to synthesize purine and pyrimidine de novo, since they only possess the sequences which encode salvage pathway enzymes. Comparative analyses of M. synoviae and M. hyopneumoniae with other Mollicutes have revealed differential genes in the former two genomes coding for enzymes that participate in carbohydrate, amino acid and nucleotide metabolism and host-pathogen interaction. The identification of these metabolic pathways will provide a better understanding of the biology and pathogenicity of these organisms.
Licença: Genetics and Molecular Biology - Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons (Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000200004&lng=pt&nrm=iso&tlng=en. Acesso em: 21 mar. 2013.
DOI: http://dx.doi.org/10.1590/S1415-47572007000200004
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