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Title: The antioxidant action of Polypodium leucotomos extract and kojic acid : reactions with reactive oxygen species
Authors: Gomes, Anderson de Jesus
Lunardi, Claure Nain
Gonzalez, Salvador
Tedesco, Antonio Claudio
Assunto:: Polipódio
Antioxidantes
Radicais livres (Química)
Ácido kójico
Issue Date: Nov-2001
Publisher: Associação Brasileira de Divulgação Científica
Citation: GOMES, A.J. et al. The antioxidant action of Polypodium leucotomos extract and kojic acid: reactions with reactive oxygen species. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 34, n. 11, nov. 2001. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001100018&lng=pt&nrm=iso>. Acesso em: 8 nov. 2012. http://dx.doi.org/10.1590/S0100-879X2001001100018.
Abstract: Two natural products Polypodium leucotomos extract (PL) and kojic acid (KA) were tested for their ability to scavenge reactive oxygen species (•OH, •O2-, H2O2, 1O2) in phosphate buffer. Hydroxyl radicals were generated by the Fenton reaction, and the rate constants of scavenging were 1.6 x 109 M-1 s-1 for KA and 1.0 x 109 M-1 s-1 for PL, similar to that of ethanol (1.4 x 109 M-1 s-1). With superoxide anions generated by the xanthine/hypoxanthine system, KA and PL (0.2-1.0 mg/ml) inhibited •O2-dependent reduction of nitroblue tetrazolium by up to 30 and 31%, respectively. In the detection of 1O2 by rose bengal irradiation, PL at 1.0 mg/ml quenched singlet oxygen by 43% relative to azide and KA by 36%. The present study demonstrates that PL showed an antioxidant effect, scavenging three of four reactive oxygen species tested here. Unlike KA, PL did not significantly scavenge hydrogen peroxide.
Licença:: Brazilian Journal of Medical and Biological Research - Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons (Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)). Fonte: http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=pt&nrm=iso. Acesso em: 8 nov. 2012.
DOI: http://dx.doi.org/10.1590/S0100-879X2001001100018
Appears in Collections:FCE-FIS - Artigos publicados em periódicos

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