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dc.contributor.authorMorais, José Athayde Vasconcelos-
dc.contributor.authorBarros, Pedro Henrique Aragão-
dc.contributor.authorBrígido, Marcelo de Macedo-
dc.contributor.authorMarina, Clara Luna-
dc.contributor.authorBocca, Anamélia Lorenzetti-
dc.contributor.authorMariano, André de Lima e Silva-
dc.contributor.authorSouza, Paulo Eduardo Narcizo de-
dc.contributor.authorPaiva, Karen Letycia Rodrigues de-
dc.contributor.authorSimões, Marina Mesquita-
dc.contributor.authorBáo, Sonia Nair-
dc.contributor.authorCamargo, Luana Cristina-
dc.contributor.authorLongo, João Paulo Figueiró-
dc.contributor.authorMorais, Amanda Alencar Cabral-
dc.contributor.authorAzevedo, Ricardo Bentes de-
dc.contributor.authorFonseca, Marcio José Poças-
dc.contributor.authorMuehlmann, Luis Alexandre-
dc.date.accessioned2025-02-20T14:34:30Z-
dc.date.available2025-02-20T14:34:30Z-
dc.date.issued2024-09-06-
dc.identifier.citationMORAIS, José Athayde Vasconcelos et al. Direct and abscopal antitumor responses elicited by AlPcNE-mediated photodynamic therapy in a Murine melanoma model. Pharmaceutics, [S. l.], v. 16, n. 9, 1177, 2024. DOI: https://doi.org/10.3390/pharmaceutics16091177. Disponível em: https://www.mdpi.com/1999-4923/16/9/1177. Acesso em: 17 fev. 2025.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/51697-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleDirect and abscopal antitumor responses elicited by AlPcNE-mediated photodynamic therapy in a Murine melanoma modelpt_BR
dc.typeArtigopt_BR
dc.subject.keywordSistema imunológicopt_BR
dc.subject.keywordImunoterapiapt_BR
dc.subject.keywordNanoemulsãopt_BR
dc.subject.keywordMelanomapt_BR
dc.rights.licenseThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/pharmaceutics16091177pt_BR
dc.description.abstract1Melanoma, the most aggressive form of skin cancer, presents a major clinical challenge due to its tendency to metastasize and recalcitrance to traditional therapies. Despite advances in surgery, chemotherapy, and radiotherapy, the outlook for advanced melanoma remains bleak, reinforcing the urgent need for more effective treatments. Photodynamic therapy (PDT) has emerged as a promising alternative, leading to targeted tumor destruction with minimal harm to surrounding tissues. In this study, the direct and abscopal antitumor effects of PDT in a bilateral murine melanoma model were evaluated. Although only one of the two tumors was treated, effects were observed in both. Our findings revealed significant changes in systemic inflammation and alterations in CD4+ and CD8+ T cell populations in treated groups, as evidenced by blood analyses and flow cytometry. High-throughput RNA sequencing (RNA-Seq) further unveiled shifts in gene expression profiles in both treated and untreated tumors. This research sheds light on the novel antitumor and abscopal effects of nanoemulsion of aluminum chloride phthalocyanine (AlPcNE)-mediated PDT in melanoma, highlighting the potential of different PDT protocols to modulate immune responses and to achieve more effective and targeted cancer treatmentspt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3067-4842pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7136-7059pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0819-0756pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3323-5300pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8013-8250pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4289-8678pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2098-4401pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9814-5827pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9873-3098pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7223-037Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5154-7263pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6974-0889pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2137-9588pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4711-7583pt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilandia, Laboratory of Nanoscience and Immunologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Gene Regulation and Mutagenesispt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Gene Regulation and Mutagenesispt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Gene Regulation and Mutagenesispt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Laboratory of Applied Immunologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Laboratory of Applied Immunologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Physics, Laboratory for Softwares and Physics Instrumentation Developmentpt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Physics, Laboratory for Softwares and Physics Instrumentation Developmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Microscopy and Microanalysispt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Microscopy and Microanalysispt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Microscopy and Microanalysispt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Gene Regulation and Mutagenesispt_BR
dc.description.unidadeFaculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândiapt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Genética e Morfologia (IB GEM)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
dc.description.unidadeInstituto de Física (IF)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Biologia Animalpt_BR
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