Título:	Trabecular and cortical mandibular bone investigation in familial adenomatous polyposis patients
Autor(es):	Pereira, Camila Pacheco de Oliveira Barbosa, Yuri Silvestre Almeida, Fabiana T. Geha, Hassem Leite, André Ferreira Guerra, Eliete Neves da Silva
Afiliação do autor:	University of Alberta, Faculty of Medicine and Dentistry, School of Dentistry, Alberta, Canada University of Texas Health, Department of Comprehensive Dentistry, School of Dentistry, San Antonio, USA University of Brasília, Health Sciences Faculty, Brasília, Brazil University of Brasília, Health Sciences Faculty, Brasília, Brazil University of Alberta, Faculty of Medicine and Dentistry, School of Dentistry, Alberta, Canada University of Texas Health, Department of Comprehensive Dentistry, School of Dentistry, San Antonio, USA University of Brasília, Health Sciences Faculty, Brasília, Brazil University of Brasília, Health Sciences Faculty, Brasília, Brazil
Assunto:	Polipose adenomatosa familiar Cólon (Anatomia) - câncer Alterações ósseas
Data de publicação:	28-Abr-2021
Editora:	Springer Nature
Referência:	PACHECO-PEREIRA, Camila et al. Trabecular and cortical mandibular bone investigation in familial adenomatous polyposis patients. Scientific Reports, [S. l.], v. 11, art. n. 9143, 2021. DOI: https://doi.org/10.1038/s41598-021-88513-z. https://www.nature.com/articles/s41598-021-88513-z. Acesso em: 10 fev. 2025.
Abstract:	Mandibular cortical and trabecular bone abnormalities in patients with familial adenomatous polyposis (FAP) were evaluated using dental panoramic radiographs (DPR) radiomorphometric indices and fractal dimension (FD). Sixty DPRs from 15 FAP patients and 45 healthy controls were evaluated. FAP group was composed of 33.3% females and 66.6% males, agemean = 37.2 years (SD 15.79). The non FAP group was paired by gender and sex. The parameters analyzed were: FD of the trabecular bone in four regions of interest (ROI), mandibular cortical index (MCI) and width (MCW). FD values were lower for the FAP group. Statistically signifcance diferences were shown by ROI 2 and 3 anteriorly to the mental foramen bilaterally, p= 0.001, and p= 0.006. The ROI 1 and 4, at the mandibular angle trabeculae, indicated statistical signifcances on the right side (p= 0.036) and no diferences on the left side (p= 0.091). There was no signifcant diference in MCI and MCW when the groups were compared, MCW (L) p= 0.247, and MCW (R) p= 0.070. Fractal values of FAP patients’ mandibular trabecular bone were lower than healthy controls. The radiomorphometric indices MCI and MCW were not useful for analyzing the cortical bone pattern. Therefore, FD is a promising tool for detection of abnormal bone structure in DPRs and for supporting the appropriate referral of FAP patients.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências da Saúde
Licença:	Open Access Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
DOI:	https://doi.org/10.1038/s41598-021-88513-z
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