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dc.contributor.authorGonçalves, Ana Beatriz Castro-
dc.contributor.authorFratelli, Caroline Ferreira-
dc.contributor.authorSiqueira, Jhon Willatan Saraiva-
dc.contributor.authorDuarte, Ligia Canongia de Abreu Cardoso-
dc.contributor.authorBarros, Aline Ribeiro-
dc.contributor.authorPossatti, Isabella-
dc.contributor.authorSantos, Maurício Lima dos-
dc.contributor.authorSilva, Calliandra Maria de Souza-
dc.contributor.authorSilva, Izabel Cristina Rodrigues da-
dc.date.accessioned2025-02-03T14:41:10Z-
dc.date.available2025-02-03T14:41:10Z-
dc.date.issued2022-
dc.identifier.citationGONÇALVES, Ana Beatriz Castro et al. MAOA uVNTR genetic variant and major depressive disorder: a systematic review. Cells, [S. l.], v. 11, n. 20, 3267, 2022. DOI: https://doi.org/10.3390/cells11203267. Disponível em: https://www.mdpi.com/2073-4409/11/20/3267. Acesso em: 03 fev. 2025.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/51436-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleMAOA uVNTR genetic variant and major depressive disorder : a systematic reviewpt_BR
dc.typeArtigopt_BR
dc.subject.keywordTranstorno depressivo maiorpt_BR
dc.subject.keywordMonoaminaspt_BR
dc.subject.keywordPolimorfismo genéticopt_BR
dc.subject.keywordFarmacogenéticapt_BR
dc.rights.license(CC BY) This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)pt_BR
dc.identifier.doihttps://doi.org/10.3390/cells11203267pt_BR
dc.description.abstract1Major Depressive Disorder (MDD) is a highly prevalent multifactorial psychopathology affected by neurotransmitter levels. Monoamine Oxidase A (MAOA) influences several neural pathways by modulating these levels. This systematic review (per PRISMA protocol and PECOS strategy) endeavors to understand the MAOA uVNTR polymorphism influence on MDD and evaluate its 3R/3R and 3R* genotypic frequencies fluctuation in MDD patients from different populations. We searched the Web of Science, PubMed, Virtual Health Library, and EMBASE databases for eligible original articles that brought data on genotypic frequencies related to the MAOA uVNTR variant in patients with MDD. We excluded studies with incomplete data (including statistical data), reviews, meta-analyses, and abstracts. Initially, we found 43 articles. After removing duplicates and applying the inclusion/exclusion criteria, seven articles remained. The population samples studied were predominantly Asians, with high 3R and 4R allele frequencies. Notably, we observed higher 3R/3R (female) and 3R* (male) genotype frequencies in the healthy control groups and higher 4R/4R (female) and 4R* (male) genotype frequencies in the MDD groups in the majority of different populations. Despite some similarities in the articles analyzed, there is still no consensus on the MAOA uVNTR variant’s role in MDD pathogenesis.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6339-8939pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0511-9452pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9064-0735pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6836-3583pt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Ceilândia, Pharmacy Coursept_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Ceilândia, Postgraduate Program in Health Sciences and Technologiespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Ceilândia, Pharmacy Coursept_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Ceilândia, Postgraduate Program in Health Sciences and Technologiespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Ceilândia, Postgraduate Program in Health Sciences and Technologiespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Ceilândia, Postgraduate Program in Health Sciences and Technologiespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Ceilândia, Pharmacy Department, Clinical Analysis Laboratory, Molecular Pathology Sectorpt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Ceilândia, Pharmacy Department, Clinical Analysis Laboratory, Molecular Pathology Sectorpt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Ceilândia, Pharmacy Department, Clinical Analysis Laboratory, Molecular Pathology Sectorpt_BR
dc.description.unidadeFaculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândiapt_BR
dc.description.unidadeCurso de Farmácia (FCTS-FAR)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências e Tecnologias em Saúdept_BR
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