Título:	Novel sustainable-by-design HDAC inhibitors for the treatment of Alzheimer’s disease
Autor(es):	Romeiro, Luiz Antonio Soares Nunes, Jéssica Larissa da Costa Miranda, Camila de Oliveira Cardoso, Gabriella Simões Heyn Roth Oliveira, Andressa Souza de Gandini, Annachiara Kobrlova, Tereza Soukup, Ondrej Rossi, Michele Senger, Johanna Jung, Manfred Gervasoni, Silvia Vistoli, Giulio Petralla, Sabrina Massenzio, Francesca Monti, Barbara Bolognesi, Maria Laura
ORCID:	http://orcid.org/0000-0002-2888-9636 http://orcid.org/0000-0002-6361-7716 http://orcid.org/0000-0002-3939-5172 http://orcid.org/0000-0002-1289-5361
Afiliação do autor:	University of Brasília, Health Sciences Faculty, Department of Pharmacy Catholic University of Brasilia, LADETER University of Brasília, Health Sciences Faculty, Department of Pharmacy University of Brasília, Health Sciences Faculty, Department of Pharmacy University of Brasília, Health Sciences Faculty, Department of Pharmacy University of Brasília, Health Sciences Faculty, Department of Pharmacy Alma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology Scuola Internazionale Superiore di Studi Avanzati (SISSA), Department of Neuroscience, Laboratory of Prion Biology University Hospital Hradec Kralove, Biomedical Research Center University Hospital Hradec Kralove, Biomedical Research Center Alma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology University of Freiburg, Institute of Pharmaceutical Sciences University of Freiburg, Institute of Pharmaceutical Sciences University of Milan, Department of Pharmaceutical Science University of Milan, Department of Pharmaceutical Science Alma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology Alma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology Alma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology Alma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology
Assunto:	Alzheimer, Doença de Castanha de caju Medicamentos Imunomodulação
Data de publicação:	29-Mar-2019
Editora:	American Chemical Society
Referência:	ROMEIRO, Luiz Antonio Soares et al. Novel sustainable-by-design HDAC inhibitors for the treatment of Alzheimer’s disease. ACS Medicinal Chemistry Letters, v. 10, n. 4, 671–676, 2019. DOI: 10.1021/acsmedchemlett.9b00071.
Abstract:	Alzheimer’s disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050. Thus, the development of sustainable drugs has attracted much attention in recent years. In light of this, taking inspiration from the HDAC inhibitor vorinostat (1), we develop the first HDAC inhibitors derived from cashew nut shell liquid (CNSL), an inexpensive agro-food waste material. CNSL derivatives 8 and 9 display a HDAC inhibitory profile similar to 1, together with a more promising safety for 9 compared to 1. Moreover, both compounds and particularly 9 were able to effectively modulate glial cell-induced inflammation and to revert the pro-inflammatory phenotype. All these results demonstrate that the use of inexpensive food waste materials could be successfully applied for the development of accessible and sustainable drug candidates for the treatment of AD.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR)
DOI:	10.1021/acsmedchemlett.9b00071
Versão da editora:	https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00071
Aparece nas coleções:	Artigos publicados em periódicos e afins

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