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dc.contributor.authorAraújo, Ananda de Mesquita-
dc.contributor.authorArruda, Sandra Fernandes-
dc.date.accessioned2024-06-05T12:21:24Z-
dc.date.available2024-06-05T12:21:24Z-
dc.date.issued2024-01-11-
dc.identifier.citationARAÚJO, Ananda de Mesquita; ARRUDA, Sandra FErnandes. Ameliorating the impairment of glucose utilization in a high-fat diet-induced obesity model through the consumption of Tucum do-Cerrado (Bactris Setosa Mart.). Plos One, [S. l.], v. 19, n. 1, 11 jan. 2024. DOI: https://doi.org/10.1371/journal.pone.0293627. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0293627. Acesso em: 05 jun.02024.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/48159-
dc.language.isoengpt_BR
dc.publisherPlos Onept_BR
dc.rightsAcesso Abertopt_BR
dc.titleAmeliorating the impairment of glucose utilization in a high-fat diet-induced obesity model through the consumption of Tucum do-Cerrado (Bactris Setosa Mart.)pt_BR
dc.typeArtigopt_BR
dc.subject.keywordDietaspt_BR
dc.subject.keywordAntioxidantespt_BR
dc.subject.keywordGlicosept_BR
dc.subject.keywordGlicogêniopt_BR
dc.subject.keywordObesidadept_BR
dc.subject.keywordTucumpt_BR
dc.rights.license© 2024 Araújo, Arruda. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0293627pt_BR
dc.description.abstract1Introduction We evaluated the effect of Tucum-do-Cerrado on glucose metabolism homeostasis and its relationship with redox-inflammatory responses in a high-fat (HF) diet-induced obesity model. Results The HF diet increased energy intake, feed efficiency, body weight, muscle and hepatic glycogen, insulin, homeostatic model assessment of insulin resistance (HOMA IR) and beta (β)-cell function, and gut catalase (CAT) activity, and decreased food intake, hepatic glutathione reductase (GR), glutathione peroxidase (GPX), glutathione S-transferase (GST), and superoxide dismutase (SOD) activities, hepatic phosphoenolpyruvate carboxykinase 1 (Pck1), and intestinal solute carrier family 5 member 1 (Slc5a1) mRNA levels compared with the control diet. However, the HF diet with Tucum-do-Cerrado decreased hepatic glycogen, and increased hepatic GR activity, hepatic Slc2a2 mRNA levels and serum Tnfa compared with the HF diet. Tucum-do-Cerrado decreased muscle glycogen, intestinal CAT and GPX activities, muscle PFK-1 and HK activities, and increased hepatic protein (CARB) and intestinal lipid (MDA) oxidation, hepatic GST activity, serum antioxidant potential, hepatic phosphofructokinase-1 (PFK-1) activity, intestinal solute carrier family 2 member 2 (Slc2a2), tumor necrosis factor (Tnf), interleukin-1 beta (Il1b), muscle protein kinase AMP-activated alpha 1 (Prkaa1), solute carrier family 2 member 2 (Slc2a2) mRNA levels, and serum interleukin-6 (IL-6) levels, regardless of diet type. Conclusion Tucum-do-Cerrado consumption may ameliorate impaired glucose utilization in a HF diet-induced obesity model by increasing liver and muscle glucose uptake and oxidation. These data suggest that Tucum-do-Cerrado consumption improves muscle glucose oxidation in non-obese and obese rats. This response may be related to the improvement in the total antioxidant capacity of rats.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1496-4527pt_BR
dc.contributor.affiliationUniversidade de Brasília, Faculty of Health Sciences, Graduate Program in Human Nutritionpt_BR
dc.contributor.affiliationUniversidade de Brasília, Faculty of Health Sciences, Department of Nutritionpt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Nutrição (FS NUT)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Nutrição Humanapt_BR
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