Título:	Body mass trajectory from diagnosis to the end of treatment in a pediatric acute lymphoblastic leukemia cohort
Autor(es):	Galati, Paula Cristina Rocha, Priscilla Roberta Silva Gruezo, Nádia Dias Amato, Angélica Amorim
ORCID:	https://orcid.org/0000-0002-8454-5504
Afiliação do autor:	University of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacology Children’s Hospital of Brasilia José Alencar University of Brasilia, Faculty of Ceilândia Children’s Hospital of Brasilia José Alencar University of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacology
Assunto:	Leucemia linfoblástica aguda (LLA) Câncer - tratamento Câncer - crianças
Data de publicação:	21-Ago-2023
Editora:	Springer Nature
Referência:	GALATI, Paula Cristina et al. Body mass trajectory from diagnosis to the end of treatment in a pediatric acute lymphoblastic leukemia cohort. Scientific Reports, [S.l.], v. 13, 21 ago. 2023. DOI: https://doi.org/10.1038/s41598-023-39287-z. Disponível em: https://www.nature.com/articles/s41598-023-39287-z#citeas. Acesso em: 23 março 2024.
Abstract:	The advances in pediatric acute lymphoblastic leukemia (ALL) care have substantially increased survival, and the late effects of treatment are a growing concern. Obesity development is frequent following ALL therapy and may significantly contribute to long-term morbidity and mortality. We examined the body mass trajectory of 208 children with ALL, from the diagnosis to the completion of therapy. We found that 7.2% of children were overweight or obese at diagnosis, which increased to 19.7% at the end of induction therapy and 20.8% after completion of treatment. In a multivariable linear regression model, age at ALL diagnosis, the type of chemotherapy regimen, and body mass index (BMI) z-score at diagnosis were significant predictors of BMI z-score after induction therapy, whereas BMI z-score at diagnosis was the only significant predictor of BMI z-score at the completion of treatment. In a subgroup of 120 children, we found no association between nutrition status at diagnosis and the risk of ALL relapse or poorer overall survival. Our findings indicate that weight gain occurs early during ALL therapy and is predicted by weight status at diagnosis. Therefore, nutritional status should be assessed throughout treatment, and weight management interventions should be considered early, particularly for patients with higher weight at diagnosis.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR) Faculdade UnB Ceilândia (FCE) Curso de Enfermagem (FCE-ENF)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências da Saúde
Licença:	© The Author(s) 2023. Open Access Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
DOI:	https://doi.org/10.1038/s41598-023-39287-z
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