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dc.contributor.authorMalard, Patrícia Furtado-
dc.contributor.authorPeixer, Mauricio Antônio da Silva-
dc.contributor.authorGrázia, João Gabriel Viana de-
dc.contributor.authorBrunel, Hilana dos Santos Sena-
dc.contributor.authorFéres, Luiz Fernando Rodrigues-
dc.contributor.authorVillarroel, Carla Lujan Pereira-
dc.contributor.authorSiqueira, Luiz Gustavo Bruno-
dc.contributor.authorDode, Margot Alves Nunes-
dc.contributor.authorPogue, Robert-
dc.contributor.authorViana, João Henrique Moreira-
dc.contributor.authorCarvalho, Juliana Lott de-
dc.date.accessioned2024-03-19T13:21:58Z-
dc.date.available2024-03-19T13:21:58Z-
dc.date.issued2020-05-15-
dc.identifier.citationMALARD, Patrícia F. et al. Intraovarian injection of mesenchymal stem cells improves oocyte yield and in vitro embryo production in a bovine model of fertility loss. Scientific Reports, v. 10, art. n. 8018, 2020. DOI: https://doi.org/10.1038/s41598-020-64810-x. Disponível em: https://www.nature.com/articles/s41598-020-64810-x. Acesso em: 19 mar. 2024.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/48004-
dc.language.isoengpt_BR
dc.publisherSpringer Naturept_BR
dc.rightsAcesso Abertopt_BR
dc.titleIntraovarian injection of mesenchymal stem cells improves oocyte yield and in vitro embryo production in a bovine model of fertility losspt_BR
dc.typeArtigopt_BR
dc.subject.keywordReprodução animalpt_BR
dc.subject.keywordCélulas-tronco mesenquimaispt_BR
dc.subject.keywordBovino - embriãopt_BR
dc.rights.license(CC BY) Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre ative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.pt_BR
dc.identifier.doihttps://doi.org/10.1038/s41598-020-64810-xpt_BR
dc.description.abstract1Valuable female cattle are continuously subject to follicular puncture (ovum pick-up - OPU). This technique is commonly used for in-vitro embryo production, but may result in ovarian lesion. Mesenchymal stem cells (MSC) ameliorate the function of injured tissues, but their use to treat ovarian lesions in cattle has not been established. We investigated whether a local injection of MSC would reduce the negative efects of repeated OPU under acute and chronic scenarios in bovines. First, we performed four OPU sessions and injected 2.5×106 MSCs immediately after the 4th OPU procedure (n=5). The treated organs (right ovary) were compared to their saline-treated counterparts (left), and presented superior production of oocytes and embryos in the three following OPU sessions (P<0.05). Then, cows with progressive fertility loss went through three OPU sessions. Animals received MSC, saline, or MSC+FSH in both ovaries after the frst OPU. In the two following OPU sessions, the MSC and MSC +FSH - treated groups failed to present any signifcant alteration in the number of oocytes and embryos compared to saline-treated animals. Thus, MSC have benefcial efects on the fertility of OPU lesioned cows, but not in cows with cystic ovarian disease and chronic ovarian lesions.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3073-4748pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9118-7768pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9976-681Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9425-1593pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7566-2859pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5125-9798pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2800-5829pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1096-0457pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8789-3512pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3742-2368pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1423-0523pt_BR
dc.contributor.affiliationUniversidade Católica de Brasíliapt_BR
dc.contributor.affiliationBio Biotecnologia da Reprodução Animalpt_BR
dc.contributor.affiliationUniversidade Católica de Brasíliapt_BR
dc.contributor.affiliationBio Biotecnologia da Reprodução Animalpt_BR
dc.contributor.affiliationCenatte Embrioespt_BR
dc.contributor.affiliationBio Biotecnologia da Reprodução Animalpt_BR
dc.contributor.affiliationUniversidade de Alfenaspt_BR
dc.contributor.affiliationBio Biotecnologia da Reprodução Animalpt_BR
dc.contributor.affiliationEmpresa Brasileira de Pesquisa Agropecuária - EMBRAPA Gado de Leitept_BR
dc.contributor.affiliationEmpresa Brasileira de Pesquisa Agropecuária - EMBRAPA Recursos Genéticos e Biotecnologiapt_BR
dc.contributor.affiliationUniversidade Católica de Brasíliapt_BR
dc.contributor.affiliationEmpresa Brasileira de Pesquisa Agropecuária - EMBRAPA Recursos Genéticos e Biotecnologiapt_BR
dc.contributor.affiliationUniversidade Católica de Brasíliapt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
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