Aqueous-based nanoemulsion containing (-)-α-bisabolol for topical treatment of skin burns

Almeida, Edson A. T.; Nunes, Ricardo Ferreira; Aguiar, Beatriz Regina Lima de; Reis, Paula Elaine Diniz dos; Gratieri, Taís; Cunha Filho, Marcílio Sérgio Soares da; Gelfuso, Guilherme Martins

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Campo DC	Valor	Idioma
dc.contributor.author	Almeida, Edson A. T.	-
dc.contributor.author	Nunes, Ricardo Ferreira	-
dc.contributor.author	Aguiar, Beatriz Regina Lima de	-
dc.contributor.author	Reis, Paula Elaine Diniz dos	-
dc.contributor.author	Gratieri, Taís	-
dc.contributor.author	Cunha Filho, Marcílio Sérgio Soares da	-
dc.contributor.author	Gelfuso, Guilherme Martins	-
dc.date.accessioned	2024-01-03T14:53:34Z	-
dc.date.available	2024-01-03T14:53:34Z	-
dc.date.issued	2021-07-09	-
dc.identifier.citation	ALMEIDA, Edson A. T. et al. Aqueous-based nanoemulsion containing (-)-α-bisabolol for topical treatment of skin burns. Current Cosmetic Science, [S. l.], v. 1, n. 1, e090721194664, 2022. DOI: 10.2174/2666779701666210709113113.	pt_BR
dc.identifier.uri	http://repositorio2.unb.br/jspui/handle/10482/47154	-
dc.language.iso	eng	pt_BR
dc.publisher	Bentham Science	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.title	Aqueous-based nanoemulsion containing (-)-α-bisabolol for topical treatment of skin burns	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Pele - ferimentos e lesões	pt_BR
dc.subject.keyword	Nanoemulsão	pt_BR
dc.subject.keyword	Medicamentos	pt_BR
dc.subject.keyword	Camomila - flores	pt_BR
dc.identifier.doi	10.2174/2666779701666210709113113	pt_BR
dc.relation.publisherversion	https://www.eurekaselect.com/article/116601	pt_BR
dc.description.abstract1	Background: α-Bisabolol (BIS) is a sesquiterpene extracted from the chamomile flowers, whose use to topically treat burn skin has been reported. High lipophilicity of BIS, however, is a problem for both skin application and washing. Objective: The present study aimed to prepare and characterize a stable and safe aqueous-based nanoemulsion to incorporate BIS and favor skin penetration focusing on skin burns' topical treatment. Methods: Oil-in-water nanoemulsions were obtained from a pseudo-ternary phase diagram. The selected nanoemulsion was characterized (droplet size, PDI, and zeta potential), and the stability was assessed for 60 days at 6ºC and room temperature. The irritability of the formulation was determined by HET-CAM. Skin permeation studies were carried out in vitro intact skin, hot water burn skin, and hot plate burn skin. Results: The nanoemulsion incorporated 1% (w/w) BIS, presented droplets' size of 14.0±0.8 nm (PDI= 0.13±0.02), the zeta potential of +7.5±1.9 mV, and was physically stable over 60 days. The HET-CAM did not show any irritability process provided by the nanoformulation. In the skin permeation experiments, when compared to an oily control solution of BIS, nanoemulsion increased 3.7-fold penetration of the drug in intact skin, likely because the nanoformulation acted as an absorption drug enhancer. On a hot water burn skin model, the increase in drug penetration was 1.7-fold, and in the hot plate burn skin, it was 2.3-fold. Conclusion: The nanoemulsion seems to be a promising alternative for skin burns' topical treatment using this natural active.	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0003-0394-0500	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0002-9782-3366	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0001-6481-2364	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0002-9167-6852	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0002-1924-7885	pt_BR
dc.description.unidade	Faculdade de Ciências da Saúde (FS)	pt_BR
dc.description.unidade	Departamento de Enfermagem (FS ENF)	pt_BR
dc.description.unidade	Departamento de Farmácia (FS FAR)	pt_BR
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