Título:	Effect of exposure to a light‑emitting diode (LED) on the physicochemical characteristics of natural latex biomembranes used to treat diabetic ulcers
Autor(es):	Santana, Thamis Fernandes Oliveira, Rebeca Hannah de Melo Santos, Ludmila Evangelista dos Lima, Eunice Paloma Nascimento Faria, Sylvia de Sousa Fonseca, Marcos Augusto Moutinho Silva, Jaqueline Rodrigues da Tatmatsu‑Rocha, José Carlos Gomes, Marília Miranda Forte Rosa, Mário Fabrício Fleury Rosa, Suélia de Siqueira Rodrigues Fleury Carneiro, Marcella Lemos Brettas
E-mail do autor:	mailto:marbretas@unb.br
ORCID:	https://orcid.org/0000-0003-1516-9426 https://orcid.org/0000-0003-2992-5747 https://orcid.org/0000-0002-9125-0018 https://orcid.org/0000-0001-6552-7143 https://orcid.org/0000-0001-9113-9005 https://orcid.org/0000-0002-6017-7057 https://orcid.org/0000-0003-4900-4857 https://orcid.org/0000-0001-8584-9676 https://orcid.org/0000-0002-4821-9007 https://orcid.org/0000-0002-1247-9050 https://orcid.org/0000-0002-6165-0969
Assunto:	Borracha natural Fototerapia Materiais biocompatíveis Cicatrização de feridas
Data de publicação:	14-Jun-2022
Editora:	Springer
Referência:	SANTANA, Thamis Fernandes et. al. Effect of exposure to a light‑emitting diode (LED) on the physicochemical characteristics of natural latex biomembranes used to treat diabetic ulcers. Research on Biomedical Engineering, n. 38, p. 901–911, 2022. DOI 10.1007/s42600-022-00226-y. Disponível em: https://link.springer.com/article/10.1007/s42600-022-00226-y. Acesso em: 11 nov. 2022.
Abstract:	Purpose Natural latex biomembrane has shown high therapeutic potential for the treatment of diabetic ulcers when associated with phototherapy. In this study, physical and chemical alterations in the latex biomembranes were evaluated after exposure to light-emitting diode (LED) irradiation and after contact with NaCl solution. Methods There were three experimental groups: natural latex biomembranes (1) in natura; (2) after 35 min of LED light irradiation; and (3) after immersion in NaCl 0.9 g% solution. The samples were analyzed by tensile strength test, thermogravimetry, contact angle wettability, and Fourier-transform infrared spectroscopy. Results The biomembranes that were submitted to contact with NaCl aqueous solution or exposure to LED did not undergo impairment of mechanical resistance. The thermogravimetry analysis indicated that increasing temperature led to mass loss in all samples, referring to their decomposition temperatures. In the wettability test, biomembranes exposed to LED showed a signifcant reduction in the contact angle between 0 and 10 min, indicating an increase in hydrophilicity, suggesting water storage capacity. The Fourier-transform infrared spectrometry assay showed that there was a more signifcant reduction in vibration intensity after immersion in NaCl solution compared to untreated biomembranes. An increase in the intensity of the entire spectrum of biomembranes exposed to LED was observed in comparison with the other samples, which may be related to photodegradation caused by LED light irradiation. Conclusion The biomembranes underwent signifcant changes in its chemical structure after being subjected to diferent types of exposure and maintained its elasticity and tensile strength properties, in addition to showing good water retention capacity after exposure to LED. Thus, it maintains many of its properties for application as a tissue-regenerating biomaterial, even when subjected to LED irradiation and a humid environment.
DOI:	https://doi.org/10.1007/s42600-022-00226-y
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