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dc.contributor.authorCerqueira, Selma Regina Penha Silva-
dc.contributor.authorDeps, Patrícia Duarte-
dc.contributor.authorCunha, Débora Vilela-
dc.contributor.authorBezerra, Natanael Victor Furtunato-
dc.contributor.authorBarroso, Daniel Holanda-
dc.contributor.authorPinheiro, Ana Bárbara Sapienza-
dc.contributor.authorPillegi, Gecilmara Salviato-
dc.contributor.authorRepsold, Taynah Alves Rocha-
dc.contributor.authorKurizky, Patricia Shu-
dc.contributor.authorCollin, Simon M.-
dc.contributor.authorGomes, Ciro Martins-
dc.date.accessioned2022-05-16T15:43:30Z-
dc.date.available2022-05-16T15:43:30Z-
dc.date.issued2021-07-28-
dc.identifier.citationCERQUEIRA, Selma Regina Penha Silva et al. The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: a prospective realworld cohort study. PLoS Neglected Tropical Diseases, v. 15, n. 7, e0009635, 2021. DOI: https://doi.org/10.1371/journal.pntd.0009635. Disponível em: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0009635. Acesso em: 16 maio 2022.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/43719-
dc.language.isoInglêspt_BR
dc.publisherPlospt_BR
dc.rightsAcesso Abertopt_BR
dc.titleThe influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19 : a prospective realworld cohort studypt_BR
dc.typeArtigopt_BR
dc.subject.keywordHanseníasept_BR
dc.subject.keywordCovid-19pt_BR
dc.rights.licenseCopyright: © 2021 Cerqueira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0009635pt_BR
dc.description.abstract1Background Protective effects of Bacillus Calmette–Gue´rin (BCG) vaccination and clofazimine and dapsone treatment against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported. Patients at risk for leprosy represent an interesting model for assessing the effects of these therapies on the occurrence and severity of coronavirus disease 2019 (COVID-19). We assessed the influence of leprosy-related variables in the occurrence and severity of COVID-19. Methodology/Principal findings We performed a 14-month prospective real-world cohort study in which the main risk factor was 2 previous vaccinations with BCG and the main outcome was COVID-19 detection by reverse transcription polymerase chain reaction (RT-PCR). A Cox proportional hazards model was used. Among the 406 included patients, 113 were diagnosed with leprosy. During follow-up, 69 (16.99%) patients contracted COVID-19. Survival analysis showed that leprosy was associated with COVID-19 (p<0.001), but multivariate analysis showed that only COVID-19-positive household contacts (hazard ratio (HR) = 8.04; 95% CI = 4.93– 13.11) and diabetes mellitus (HR = 2.06; 95% CI = 1.04–4.06) were significant risk factors for COVID-19. Conclusions/Significance Leprosy patients are vulnerable to COVID-19 because they have more frequent contact with SARS-CoV-2-infected patients, possibly due to social and economic limitations. Our model showed that the use of corticosteroids, thalidomide, pentoxifylline, clofazimine, or dapsone or BCG vaccination did not affect the occurrence or severity of COVID-19.pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-3188-4131pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-7833-552Xpt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0003-4128-1593pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-2766-3141pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0003-0054-7754pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-3220-0838pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-3220-0838pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-5759-2727pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-1239-1681pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-3069-6884pt_BR
dc.description.unidadeFaculdade de Medicina (FMD)-
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