Título:	Effect of n-3 long-chain polyunsaturated fatty acid intake on the eicosanoid profile in individuals with obesity and overweight : a systematic review and meta-analysis of clinical trials
Autor(es):	Schweitzer, Guilherme R. B. Rios, Isabela N. M. S. Gonçalves, Vivian Siqueira Santos Magalhães, Kelly Grace Pizato, Nathalia Marcolini Pelucio
ORCID:	https://orcid.org/0000-0002-7435-5272 https://orcid.org/0000-0001-5858-7076
Assunto:	Eucosanóides Inflamação n- 3 PUFA Obesidade Revisão sistemática
Data de publicação:	21-Jul-2021
Editora:	Cambridge University Press on behalf of The Nutrition Society
Referência:	SCHWEITZER, Guilherme R. B. et al. Effect of n-3 long-chain polyunsaturated fatty acid intake on the eicosanoid profile in individuals with obesity and overweight: a systematic review and meta-analysis of clinical trials. Journal of Nutritional Science, v. 10, e53, 2021. DOI: https://doi.org/10.1017/jns.2021.46. Disponível em: https://www.cambridge.org/core/journals/journal-of-nutritional-science/article/effect-of-n3-longchain-polyunsaturated-fatty-acid-intake-on-the-eicosanoid-profile-in-individuals-with-obesity-and-overweight-a-systematic-review-and-metaanalysis-of-clinical-trials/20E7644BFC5F5ED2237A40815FE6A998. Acesso em: 23 ago. 2021.
Abstract:	Dietary n-3 polyunsaturated fatty acids (PUFAs) present beneficial effects on counteracting inflammation status, displaying a critical anti-inflammatory role and maintaining physiological homeostasis in obesity. The primary objective of this systematic review was to evaluate the effect of n-3 PUFAs intake on the eicosanoid profile of people with obesity and overweight. The search strategy on Embase, Scopus, PubMed, Web of Science, Cochrane Library, Google Scholar and ProQuest was undertaken until November 2019 and updated January 2021. The effect size of n-3 PUFAs on prostaglandins was estimated by Glass's, type 1 in a random-effect model for the meta-analysis. Seven clinical trials met the eligible criteria and a total of 610 subjects were included in this systematic review, and four of seven studies were included in meta-analysis. The intake of n-3 PUFAs promoted an overall reduction in serum pro-inflammatory eicosanoids. Additionally, n-3 PUFAs intake significantly decreased the arachidonic acid COX-derived PG eicosanoid group levels (Glass's Δ −0⋅35; CI −0⋅62, −0⋅07, I2 31⋅48). Subgroup analyses showed a higher effect on periods up to 8 weeks (Glass's Δ −0⋅51; CI −0⋅76, −0⋅27) and doses higher than 0⋅5 g of n-3 PUFAs (Glass's Δ −0⋅46; CI −0⋅72, −0⋅27). Dietary n-3 PUFAs intake contributes to reduce pro-inflammatory eicosanoids of people with obesity and overweight. Subgroup's analysis showed that n-3 PUFAs can reduce the overall arachidonic acid COX-derived PG when adequate dose and period are matched.
Licença:	© The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI:	https://doi.org/10.1017/jns.2021.46
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