New perspectives on the topical management of recurrent candidiasis

Ré, Ana Carolina S.; Martins, Jayanaraian F.; Cunha Filho, Marcílio Sérgio Soares da; Gelfuso, Guilherme Martins; Aires, Carolina P.; Gratieri, Taís

Registro completo de metadados

Campo DC	Valor	Idioma
dc.contributor.author	Ré, Ana Carolina S.	-
dc.contributor.author	Martins, Jayanaraian F.	-
dc.contributor.author	Cunha Filho, Marcílio Sérgio Soares da	-
dc.contributor.author	Gelfuso, Guilherme Martins	-
dc.contributor.author	Aires, Carolina P.	-
dc.contributor.author	Gratieri, Taís	-
dc.date.accessioned	2021-05-20T14:09:39Z	-
dc.date.available	2021-05-20T14:09:39Z	-
dc.date.issued	2021-01-19	-
dc.identifier.citation	RÉ, Ana Carolina S. et al. New perspectives on the topical management of recurrent candidiasis. Drug Delivery and Translational Research, n.11, p.1568-1585, 2021. DOI: https://doi.org/10.1007/s13346-021-00901-0.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/40964	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Springer Nature	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	New perspectives on the topical management of recurrent candidiasis	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Candidíase	pt_BR
dc.subject.keyword	Reincidência	pt_BR
dc.subject.keyword	Biofilme	pt_BR
dc.subject.keyword	Tecnologia farmacêutica	pt_BR
dc.identifier.doi	https://doi.org/10.1007/s13346-021-00901-0	pt_BR
dc.relation.publisherversion	https://link.springer.com/article/10.1007%2Fs13346-021-00901-0	pt_BR
dc.description.abstract1	Candidiasis is a common opportunistic infection caused by fungi of the Candida genus that affects mainly mucocutaneous tissues (e.g., vaginal, oral, and mammary). This condition has been known for a long time; thus, innumerous topical and systemic treatments are already available on the market worldwide. Yet, recurrent superficial candidiasis (RSC) is an expected outcome, still lacking effective and convenient treatments. Although several individual conditions may contribute to disease recurrence, biofilms’ presence seems to be the main etiological factor contributing to antifungal resistance. More than proposing novel antifungal agents, current research seems to be focusing on improving the pharmaceutical technology aspects of formulations to address such a challenge. These include extending and improving intimate contact of drug delivery systems with the mucocutaneous tissues, increasing drug loading dose, and enhancing topical drug permeation. This review discusses the current understanding of the RSC and the use of pharmaceutical technology tools in obtaining better results. Even though several drawbacks of conventional formulations have been circumvented with the help of nano- or microencapsulation techniques and with the use of mucoadhesive formulation excipients, many challenges remain. In particular, the need to mask the unpalatable taste of formulations for the treatment of oral candidiasis, and the necessity of formulations with a “dryer” sensorial feeling and improved performances in providing higher bioavailability for the treatment of mammary and vaginal candidiasis.	pt_BR
Aparece nas coleções:	Artigos publicados em periódicos e afins