| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Sousa Neto, Ivo Vieira de | - |
| dc.contributor.author | Tibana, Ramires Alsamir | - |
| dc.contributor.author | Silva, Leonardo Gomes de Oliveira da | - |
| dc.contributor.author | Lira, Eliene Martins de | - |
| dc.contributor.author | Prado, Gleyce Pires Gonçalves do | - |
| dc.contributor.author | Almeida, Jeeser Alves de | - |
| dc.contributor.author | Franco, Octavio Luiz | - |
| dc.contributor.author | Durigan, João Luiz Quagliotti | - |
| dc.contributor.author | Adesida, Adetola B. | - |
| dc.contributor.author | Sousa, Marcelo Valle de | - |
| dc.contributor.author | Ricart, Carlos André Ornelas | - |
| dc.contributor.author | Damascena, Hylane Luiz | - |
| dc.contributor.author | Castro, Mariana S. | - |
| dc.contributor.author | Fontes, Wagner | - |
| dc.contributor.author | Prestes, Jonato | - |
| dc.contributor.author | Marqueti, Rita de Cássia | - |
| dc.date.accessioned | 2021-02-19T12:47:44Z | - |
| dc.date.available | 2021-02-19T12:47:44Z | - |
| dc.date.issued | 2020-06-16 | - |
| dc.identifier.citation | SOUSA NETO, Ivo de et al. Paternal resistance training modulates calcaneal tendon proteome in the offspring exposed to high-fat diet. Frontiers in Cell and Developmental Biology, v. 8, art. 380, jun. 2020. DOI: https://doi.org/10.3389/fcell.2020.00380. Disponível em: https://www.frontiersin.org/articles/10.3389/fcell.2020.00380/full. Acesso em: 19 fev. 2021. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/40091 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | Frontiers | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Paternal resistance training modulates calcaneal tendon proteome in the offspring exposed to high-fat diet | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Obesidade | pt_BR |
| dc.subject.keyword | Intergeracional | pt_BR |
| dc.subject.keyword | Programação paterna | pt_BR |
| dc.subject.keyword | Exercícios físicos | pt_BR |
| dc.subject.keyword | Tendões | pt_BR |
| dc.rights.license | Copyright © 2020 Sousa Neto, Tibana, Silva, Lira, Prado, Almeida, Franco, Durigan, Adesida, Sousa, Ricart, Damacena, Castro, Fontes, Prestes and Marqueti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | pt_BR |
| dc.identifier.doi | https://doi.org/10.3389/fcell.2020.00380 | pt_BR |
| dc.description.abstract1 | The increase in high-energy dietary intakes is a well-known risk factor for many diseases, and can also negatively impact the tendon. Ancestral lifestyle can mitigate the metabolic harmful effects of offspring exposed to high-fat diet (HF). However, the influence of paternal exercise on molecular pathways associated to offspring tendon remodeling remains to be determined. We investigated the effects of 8 weeks of paternal resistance training (RT) on offspring tendon proteome exposed to standard diet or HF diet. Wistar rats were randomly divided into two groups: sedentary fathers and trained fathers (8 weeks, three times per week, with 8–12 dynamic movements per climb in a stair climbing apparatus). The offspring were obtained by mating with sedentary females. Upon weaning, male offspring were divided into four groups (five animals per group): offspring from sedentary fathers were exposed either to control diet (SFO-C), or to high-fat diet (SFO-HF); offspring from trained fathers were exposed to control diet (TFO-C) or to a high-fat diet (TFO-HF). The Nano-LC-MS/MS analysis revealed 383 regulated proteins among offspring groups. HF diet induced a decrease of abundance in tendon proteins related to extracellular matrix organization, transport, immune response and translation. On the other hand, the changes in the offspring tendon proteome in response to paternal RT were more pronounced when the offspring were exposed to HF diet, resulting in positive regulation of proteins essential for the maintenance of tendon integrity. Most of the modulated proteins are associated to biological pathways related to tendon protection and damage recovery, such as extracellular matrix organization and transport. The present study demonstrated that the father’s lifestyle could be crucial for tendon homeostasis in the first generation. Our results provide important insights into the molecular mechanisms involved in paternal intergenerational effects and potential protective outcomes of paternal RT. | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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